Drug permeation behavior through thermo- and pH-responsive polycarbonate-g-poly(N-isopropylacrylamide-co-acrylic acid) composites

Tsai, Meng-Chao; Shih, Chao‐Ming; Lue, Shingjiang Jessie

doi:10.1007/s00289-012-0865-0

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…Figure illustrates an on–off valve mechanism designed through grafting a P(NIPAAm- co -AAc) hydrogel onto microporous films. Thus, as the environmental temperature changes, drug permeation can be regulated …”

Section: Synthesis Methods Of Thermosensitive Npsmentioning

confidence: 99%

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Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

342

212

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Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external stimulus when heat is applied from the outside, or can be internal when pathological lesions have a naturally elevated termperature. A low critical solution temperature (LCST) is a special feature of some polymeric materials, and most of the temperature-responsive nanocarriers have been designed based on this feature. In this review, we attempt to summarize recent efforts to prepare innovative temperature-responsive nanocarriers and discuss their novel applications.

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Section: Synthesis Methods Of Thermosensitive Npsmentioning

confidence: 99%

Section: Synthesis Methods Of Thermosensitive Npsmentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

342

212

View full text Add to dashboard Cite

show abstract

“…Thermal analyses of the swollen hydrogels were performed to evaluate the thermo‐responsive behavior of HB and HQ and calculate the low critical solution temperature (LCST) as the onset value of the endothermic peak, where intramolecular hydrogen bonds between water and NH‐ group break ( Figure ) . The recorded values (36.4 °C for HB and 37.1 °C for HQ) proved a significant increase of LCST in comparison with NIPAAm‐based hydrogel (LCST about 31 °C) due to the presence of hydrophilic moieties (CHIT and Q residues) in the network.…”

Section: Resultsmentioning

confidence: 99%

Chitosan–Quercetin Bioconjugate as Multi‐Functional Component of Antioxidants and Dual‐Responsive Hydrogel Networks

Cirillo

Curcio

Spizzirri

et al. 2019

Macro Materials & Eng

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Multifunctional hydrogels based on chitosan–quercetin (CHITQ) conjugate are prepared by a thermo‐induced radical procedure in the presence of N‐isopropylacrylamide (NIPAAm), acrylamide (AAm), and N,N′‐methylenebis(acrylamide) (MEBA). At first, quercetin (Q) is grafted onto chitosan backbone with a functionalization degree of 275 mg of Q per gram of conjugate, as calculated by 1H‐NMR analyses to impart antioxidant properties to the polysaccharide. Then, a pH and temperature sensitive hydrogel was obtained by involving CHITQ and NIPAAm in the polymerization reaction. The accessibility of phenolic moieties is modified in response to the hydrogel swelling/deswelling, as confirmed by antioxidant tests performed at different temperatures. Dual stimuli‐responsive hydrogels are proposed for the delivery of caffeine as model drug. The release profiles of caffeine depict a system particularly performing as on/off device at acidic pH with excellent applicability prospects.

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Characterization of hybrid copolymer containing thermosensitive and polypeptide blocks by thermogravimetric analysis

et al. 2013

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Drug permeation behavior through thermo- and pH-responsive polycarbonate-g-poly(N-isopropylacrylamide-co-acrylic acid) composites

Cited by 5 publications

References 19 publications

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Chitosan–Quercetin Bioconjugate as Multi‐Functional Component of Antioxidants and Dual‐Responsive Hydrogel Networks

Characterization of hybrid copolymer containing thermosensitive and polypeptide blocks by thermogravimetric analysis

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