Drug Nanocrystals in Oral Absorption: Factors That Influence Pharmacokinetics
Luiza de Oliveira Macedo,
Jéssica Fagionato Masiero,
Nádia Araci Bou-Chacra
Abstract:Despite the safety and convenience of oral administration, poorly water-soluble drugs compromise absorption and bioavailability. These drugs can exhibit low dissolution rates, variability between fed and fasted states, difficulty permeating the mucus layer, and P-glycoprotein efflux. Drug nanocrystals offer a promising strategy to address these challenges. This review focuses on the opportunities to develop orally administered nanocrystals based on pharmacokinetic outcomes. The impacts of the drug particle siz… Show more
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