Drug Monitoring and Viral Response to Lopinavir/Ritonavir or Saquinavir/Ritonavir Containing Regimens in Individuals Infected with the Human Immunodeficiency Virus Type1

Falkensammer, Barbara; Fasser, W; Scherer, Karin; Zemann, Andreas; Parson, Walther; Ulmer, Hanno; Mp, Dierich; Stoiber, Heribert

doi:10.1177/039463200501800115

Cited by 7 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anti-inflammatory cytokines while potentially beneficial, may in certain situations impair the host's inflammatory response. 30,31 Several factors, including the variability in microbial species and age of a patient, may influence the proinflammatory and anti-inflammatory cytokines differently [41][42][43][44][45][46][47][48] , which may result in different serum PCT levels.…”

Section: Discussionmentioning

confidence: 99%

Serial procalcitonin responses in infection of children with secondary immunodeficiency

Hatzistilianou

Rekleity

Athanassiadou

et al. 2007

CIM

View full text Add to dashboard Cite

Purpose: Procalcitonin has proven to be a sensitive inflammatory marker in non-neutropenic patients. The aim of this study was to determine and compare Procalcitonin with other inflammatory markers in the serum of immunosuppressed children with haematological malignancies; and to assess the predictive value of these mediators in distinguishing between bacterial and non-bacterial infection. Methods & Results: The study included 37 children with acute lymphoblastic leukaemia undergoing intensive chemotherapy. They were divided into 3 groups, A, B and C. Group A consisted of 29 neutropenic children with 94 febrile episodes, group B of 20 neutropenic children with 56 afebrile episodes and group C of 13 non-neutropenic children with 58 afebrile episodes. Serial serum levels of PCT, C-Reactive Protein, Neopterin, Interleukin-6 and NO2/NO3 were all determined on a day-to-day basis for 7 consecutive days. In serum the concentrations of CRP was determined by nephelometry, of PCT by immunoluminescence and of Neopterin, IL-6 and NO2/NO3 by ELISA method. Conclusions: According to our results the Procalcitonin concentration increased rapidly in patients with microbial infection; the response was detectable within 24 hs of the onset of fever due to microbial infections. Procalcitonin is a spesific and sensitive marker of microbial infection in patients with neutropenic fever. The markers, C-Reactive Protein, Interleukin-6 and NO2/NO3 may not help to identify infections and distinguishe the etiology of infection in neutropenic febrile children with acute lymphoblastic leukaemia.

show abstract

Section: Discussionmentioning

confidence: 99%

Serial procalcitonin responses in infection of children with secondary immunodeficiency

Hatzistilianou

Rekleity

Athanassiadou

et al. 2007

CIM

View full text Add to dashboard Cite

show abstract

Therapeutic drug monitoring of antiretroviral drugs in HIV-infected patients

Punyawudho

Singkham

Thammajaruk

et al. 2016

Expert Review of Clinical Pharmacology

View full text Add to dashboard Cite

Therapeutic drug monitoring (TDM) may be beneficial when applied to antiretroviral (ARV). Even though TDM can be a valuable strategy in HIV management, its role remains controversial. Areas covered: This review provides a comprehensive update on important issues relating to TDM of ARV drugs in HIV-infected patients. Articles from PubMed with keywords relevant to each topic section were reviewed. Search strategies limited to articles published in English. Expert commentary: There is evidence supporting the use of TDM in HIV treatment. However, some limitations need to be considered. The evidence supporting the use of routine TDM for all patients is limited, as it is not clear that this strategy offers any advantages over TDM for selected indications. Selected groups of patients including patients with physiological changes, patients with drug-drug interactions or toxicity, and the elderly could potentially benefit from TDM, as optimized dosing is challenging in these populations.

show abstract

The Proinflammatory Interleukin-21 Elicits Anti-Tumor Response and Mediates Autoimmunity

Castellani

Salini²,

Frydas

et al. 2006

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Drug Monitoring and Viral Response to Lopinavir/Ritonavir or Saquinavir/Ritonavir Containing Regimens in Individuals Infected with the Human Immunodeficiency Virus Type1

Cited by 7 publications

References 25 publications

Serial procalcitonin responses in infection of children with secondary immunodeficiency

Serial procalcitonin responses in infection of children with secondary immunodeficiency

Therapeutic drug monitoring of antiretroviral drugs in HIV-infected patients

The Proinflammatory Interleukin-21 Elicits Anti-Tumor Response and Mediates Autoimmunity

Contact Info

Product

Resources

About