Drug Metabolizing Enzymes and Transporters of the Mesentery

Argikar, Aneesh A.; Argikar, Upendra A.

doi:10.1007/978-3-031-17774-3_10

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2024

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“…Mesenteric pharmacokinetics remains an emerging field. 57,58 This is partially reflected in the fact that the array of biological and immunosuppressant agents in use in Crohn's disease does not alter the mesenteric landscape in this condition. Alternative treatment mechanisms must now be sought.…”

Section: Future Directionsmentioning

confidence: 99%

The Surgical Management of the Mesentery in Crohn's Disease

Coffey,

Devine

2024

Clin Colon Rectal Surg

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Increasing evidence suggests that Crohn's disease is a primary mesenteropathy and that resection of the mesentery, or its exclusion from an anastomosis, may alter disease progression. If borne out in clinical trials, this observation would be welcome, as current pharmacotherapeutic approaches to Crohn's disease appear to have limited effect on disease progression. This article explores arguments for and against the alteration of mesenteric inputs by surgical means, in Crohn's disease.

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Section: Future Directionsmentioning

confidence: 99%