Abstract:Infants and children are different from adults, also in the way they handle (pharmacokinetics, PK) and subsequently respond (pharmacodynamics) to drugs. Developmental PK focuses on developmental aspects of absorption, distribution, metabolism and excretion of drugs, subsequent potentially affecting drug pharmacological response, and safety.
All drug metabolism‐mediated phase I and II reactions display isoenzyme specific age‐dependent activity, that is, ontogeny. Several
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