Drug Metabolism and Disposition Diversity of Ranunculales Phytometabolites

In order to improve the scientificity and efficiency of quality inspection of navigation electronic map, and save the cost of quality inspection, it is necessary to establish the national navigation electronic map quality inspection sample database. In this paper, the construction goal, data acquisition technology process, and database construction method of navigation electronic map quality inspection sample database are described in detail, and the construction content and technical indicators are discussed. The quality test is carried out by combining the in-house verification with the field comparison of the navigation electronic map quality test sample database, and the test results are analyzed and evaluated. The effective application of the sample database in the quality test and evaluation of the internet navigation electronic map in the pilot area is carried out. At the same time, the application of navigation electronic map quality inspection sample database in the research of urban fine management and solid waste recycling economy ecological park planning is prospected.

show abstract

Naturally Occurring Cholinesterase Inhibitors from Plants, Fungi, Algae, and Animals: A Review of the Most Effective Inhibitors Reported in 2012-2022

Murray

Biscussi

Cavallaro

et al. 2024

View full text Add to dashboard Cite

Since the development of the “cholinergic hypothesis” as an important therapeutic approach in the treatment of Alzheimer’s disease (AD), the scientific community has made a remarkable effort to discover new and effective molecules with the ability to inhibit the enzyme acetylcholinesterase (AChE). The natural function of this enzyme is to catalyze the hydrolysis of the neurotransmitter acetylcholine in the brain. Thus, its inhibition increases the levels of this neurochemical and improves the cholinergic functions in patients with AD alleviating the symptoms of this neurological disorder. In recent years, attention has also been focused on the role of another enzyme, butyrylcholinesterase (BChE), mainly in the advanced stages of AD, transforming this enzyme into another target of interest in the search for new anticholinesterase agents. Over the past decades, Nature has proven to be a rich source of bioactive compounds relevant to the discovery of new molecules with potential applications in AD therapy. Bioprospecting of new cholinesterase inhibitors among natural products has led to the discovery of an important number of new AChE and BChE inhibitors that became potential lead compounds for the development of anti-AD drugs. This review summarizes a total of 260 active compounds from 142 studies which correspond to the most relevant (IC 50 ≤ 15 µM) research work published during 2012-2022 on plant-derived anticholinesterase compounds, as well as several potent inhibitors obtained from other sources like fungi, algae, and animals.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Drug Metabolism and Disposition Diversity of Ranunculales Phytometabolites

Cited by 3 publications

References 140 publications

A study from structural insight to the antiamyloidogenic and antioxidant activities of flavonoids: scaffold for future therapeutics of Alzheimer’s disease

A study from structural insight to the antiamyloidogenic and antioxidant activities of flavonoids: scaffold for future therapeutics of Alzheimer’s disease

Discussion on the Construction and Application of Navigation Electronic Map Quality Inspection Sample Database

Naturally Occurring Cholinesterase Inhibitors from Plants, Fungi, Algae, and Animals: A Review of the Most Effective Inhibitors Reported in 2012-2022

Contact Info

Product

Resources

About