Drug metabolism and antibiotic resistance in micro‐organisms

Abstract

Linked Articles This article is part of a themed section on Drug Metabolism and Antibiotic Resistance in Micro‐organisms. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.14/issuetoc

A robust carbon dot-based antibacterial CDs-PVA film as a wound dressing for antibiosis and wound healing

“…However, excessive use of antibiotics has seriously led to drug resistance and environmental pollution. [17][18][19][20] The rapid development of nanotechnology has opened up a new route for exploiting nanoscale antibiotic alternatives. Metal-based nanomaterials such as Au, [21][22][23][24] Ag, [25][26][27][28] ZnO, [29][30][31][32][33] Fe 3 O 4 , [34][35][36] TiO 2 , [37][38][39] CuO [40][41][42] and CuSe 43 nanoparticles have been proven to be effective bactericides, and can kill bacteria by destroying the bacterial membrane, producing ROS, depleting adenosine triphosphate, inhibiting the functions of DNA and enzymes, and interfering with the respiratory chain.…”

H2S-removing UiO-66 MOFs for sensitized antibacterial therapy

“…Several microbial metabolites, including pyocyanin, indole, phenazine 1-carboxylic acid, salicylate, and hydrogen sulfide (H 2 S), have been found to profoundly affect antibiotic resistance and antibiotic tolerance. [8][9][10] Among them, endogenous H 2 S acts as a gas transmitter to protect bacteria from antibiotic stress. Virtually all bacteria generate H 2 S through three enzymes: cystathionine g-lyase (CSE), cystathionine b-synthase (CBS), or 3-mercaptopyruvate sulfurtransferase.…”

Antibiotic Sensitivity of Clinical Isolates at Outpatient Unitin Tver, Russia: A Comparatives

“…Bacteria have accumulated special protective mechanisms and have developed resistance to antibiotics. [1,2].…”