Drug loading into porous calcium carbonate microparticles by solvent evaporation

Preisig, Daniel; Haid, David; Varum, Felipe; Bravo, Roberto; Alles, Rainer; Huwyler, Jörg; Puchkov, Maxim

doi:10.1016/j.ejpb.2014.02.009

Cited by 93 publications

(54 citation statements)

References 46 publications

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“…[41][42][43][44][45][46]. Most importantly, as we were searching for a candidate for the inorganic material for drug loading, drugs can be trapped within these hollow nano-CaCO 3 particles to effectively and efficiently deliver them to the tumors and cancer cells with some modifications [19,[47][48][49][50][51]. In the future, methods will be developed to synthesize featured hollow nano-CaCO 3 particles for drug loading and cancer therapy.…”

Section: Resultsmentioning

confidence: 99%

Rice-like hollow nano-CaCO 3 synthesis

Ulkeryildiz¹,

Kilic²,

Ozdemir³

2016

Journal of Crystal Growth

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a b s t r a c tWe have shown that Ca(OH) 2 solution is a natural stabilizer for CaCO 3 particles. We designed a CO 2 bubbling crystallization reactor to produce nano-CaCO 3 particles in homogenous size distribution without aggregation. In the experimental set-up, the crystallization region was separated from the stabilization region. The produced nanoparticles were removed from the crystallization region into the stabilization region before aggregation or crystal growth. It was shown that rice-like hollow nano-CaCO 3 particles in about 250 nm in size were produced with almost monodispersed size distribution. The particles started to dissolve through their edges as CO 2 bubbles were injected, which opened-up the pores inside the particles. At the late stages of crystallization, the open pores were closed as a result of dissolution-recrystallization of the newly synthesized CaCO 3 particles. These particles were stable in Ca(OH) 2 solution and no aggregation was detected. The present methodology can be used in drug encapsulation into inorganic CaCO 3 particles for cancer treatment with some modifications.

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Section: Resultsmentioning

confidence: 99%

Rice-like hollow nano-CaCO 3 synthesis

Ulkeryildiz¹,

Kilic²,

Ozdemir³

2016

Journal of Crystal Growth

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“…Controlled synthesis of inorganic materials with specific morphology, size, and crystallographic structure has attracted considerable attention due to the potential application in various industrial fields such as catalysis, medicine, electronics, ceramics, pigments, cosmetics, food, and so on [1][2][3][4][5]. Calcium carbonate (CaCO 3 ) is one of the most abundant existing biominerals produced by organisms, which has been widely used as an important model system for investigating inorganic precipitation reaction or crystallization [6,7].…”

Section: Introductionmentioning

confidence: 99%

High-yield synthesis of vaterite CaCO3 microspheres in ethanol/water: structural characterization and formation mechanisms

et al. 2015

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Calcium carbonate (CaCO 3 ) is widely used as an important model system for investigating inorganic precipitation reaction or crystallization. However, recent results show that the yield of vaterite CaCO 3 microspheres is poor in ethanol/water in the presence of polyelectrolyte poly(sodium 4-styrenesulfate) (PSS), which is up to 16 mM. We now report on an approach to synthesize pure vaterite CaCO 3 microspheres through improving the concentration of polymer PSS and the yield is greatly high up to 80 mM. The exploration provides the possibility for large-scale synthesis of CaCO 3 materials with controllable morphology and crystallographic structure in aqueous solution at room temperature. The possible formation mechanism toward the occurrence of vaterite CaCO 3 microspheres has also been illustrated in virtue of a series of time-resolved experimental results. It is revealed that the vaterite microspheres evolve gradually from the initial amorphous precursor, to poorly crystallized nanoparticles, to sphere-like aggregates, and then to vaterite microspheres embedded with the calcite rhombohedra, finally to the vaterite microspheres with smooth surface. This research may provide a new viewpoint into the forming process of vaterite CaCO 3 microspheres.

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“…3) did not move during the experiment and the powder compacts did not change their shape and microstructure after drying the hydrated tablets again. The results clearly demonstrate that the highly porous FCC powder was specifically designed to enhance the liquid uptake of pharmaceutical tablets (Stirnimann et al, 2013(Stirnimann et al, , 2014Preisig et al, 2014;Wagner-Hattler et al, 2017;Eberle et al, 2015Eberle et al, , 2014. The water penetration kinetics are strongly driven by the porosity of the tablets (Fig.…”

Section: Liquid Imbibitionmentioning

confidence: 81%

Resolving the rapid water absorption of porous functionalised calcium carbonate powder compacts by terahertz pulsed imaging

Markl

Wang

Ridgway

et al. 2018

Chemical Engineering Research and Design

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Cost effectiveness, ease of use and patient compliance make pharmaceutical tablets the most popular and widespread form to administer a drug to a patient. Tablets typically consist of an active pharmaceutical ingredient and a selection from various excipients. A novel highly porous excipient, functionalised calcium carbonate (FCC), was designed to facilitate rapid liquid uptake leading to disintegration times of FCC based tablets in the matter of seconds. Five sets of FCC tablets with a target porosity of 45-65% in 5% steps were prepared and characterised using terahertz pulsed imaging (TPI). The high acquisition rate (15 Hz) of TPI enabled the analysis of the rapid liquid imbibition of water into these powder compacts. The penetration depth determined from the TPI measurements as a function of time was analysed by the power law and modelled for both the inertial (initial phase) and Lucas-Washburn (LW, longer time Laplace-Poiseuillian) regimes. The analysis of the hydraulic radius estimated by fitting the liquid imbibition data to the LW equation demonstrates the impact of the porosity as well as the tortuosity of the pore channels on the liquid uptake performance. The tortuosity was related to the porosity by a geometrical model, which shows that the powder compact is constructed by aggregated particles with low permeability and its principal axis perpendicular to the compaction direction. The consideration of the tortuosity yielded a very high correlation (R 2 = 0.96) between the porosity and the hydraulic pore radius. The terahertz data also resolved fluctuations (0.9-1.3 Hz) of the liquid movement which become more pronounced and higher in frequency with increasing porosity, which is attributed to the constrictivity of pore channels. This study highlights the strong impact of a tablet's microstructure on its liquid penetration kinetics and thus on its disintegration behaviour.

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Drug loading into porous calcium carbonate microparticles by solvent evaporation

Cited by 93 publications

References 46 publications

Rice-like hollow nano-CaCO 3 synthesis

Rice-like hollow nano-CaCO 3 synthesis

High-yield synthesis of vaterite CaCO3 microspheres in ethanol/water: structural characterization and formation mechanisms

Resolving the rapid water absorption of porous functionalised calcium carbonate powder compacts by terahertz pulsed imaging

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