Drug loading, dispersion stability, and therapeutic efficacy in targeted drug delivery with carbon nanotubes

Heister, Elena; Neves, Vera; Lamprecht, Constanze; Silva, S. Ravi P.; Coley, Helen M.; McFadden, Johnjoe

doi:10.1016/j.carbon.2011.08.074

Cited by 148 publications

(63 citation statements)

References 28 publications

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“…[12][13][14][15][16][17][18][19] Liu et al 20 proposed a new drug delivery system using polyethylene glycol (PEG)-functionalized SWCNTs attached to DOX. Water-soluble SWCNTs by PEG functionalization exhibited an extremely high loading efficiency of ~400%.…”

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confidence: 99%

Carbon nanotubes as cancer therapeutic carriers and mediators

Son¹,

Hong²,

Lee³

2016

IJN

218

106

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Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appropriate functionalization, CNTs have been used as nanocarriers for anticancer drugs including doxorubicin, camptothecin, carboplatin, cisplatin, paclitaxel, Pt(II), and Pt(IV), and genes including plasmid DNA, small-interfering RNA, oligonucleotides, and RNA/DNA aptamers. CNTs can also deliver proteins and immunotherapy components. Using combinations of light energy, they have also been applied as mediators for photothermal therapy and photodynamic therapy to directly destroy cancer cells without severely damaging normal tissue. If limitations such as a long-term cytotoxicity in the body, lack of size uniformity during the synthetic process, loading deviations for drug–CNT complexes, and release controllability at the target point are overcome, CNTs will become one of the strongest tools that are available for various other biomedical fields as well as for cancer therapy.

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confidence: 99%

Carbon nanotubes as cancer therapeutic carriers and mediators

Son¹,

Hong²,

Lee³

2016

IJN

218

106

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“…CNTs are promising materials for polymer composites [4][5][6] , energy conversion [7][8][9] , sensing [10][11][12] and biological application [13][14][15][16][17] . However, processing CNT´s and introducing them into real applications is severely limited by their low solubilities in organic solvents.…”

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confidence: 99%

Structure of a carbon nanotube–dendrimer composite

et al. 2013

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Using all atomistic molecular dynamics (MD) simulations we report the microscopic picture of the nanotube-dendrimer complex for PAMAM dendrimer of generation 2 to 4 and carbon nanotube of chirality (6,5). We find compact wrapping conformations of dendrimer onto the nanotube surface for all the three generations of PAMAM dendrimer. The degree of wrapping is more for non-protonated dendrimer compared to the protonated dendrimer. For comparison we also study the interaction of another dendrimer, poly(propyl ether imine) (PETIM), with nanotube and show that PAMAM dendrimer interacts strongly as compared to PETIM dendrimer as is evident from the distance of closest approach as well as the number of close contacts between the nanotube and dendrimer. We also calculate the binding energy between the nanotube and the dendrimer using MM/PBSA methods and attribute the strong binding to the charge transfer between them. Dendrimer wrapping on CNT will make it soluble and can act as an efficient dispersing agent for nanotube.

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“…Although, drug covalent bonds keep drug tightly bound to carrier and increase the drug circulation time in the human body, but it would be more effective, if the drug delivery system can release the drug at the target position (Heister et al, 2012;Liu et al, 2007;Raffa et al, 2010). The inactive cisplatin prodrug using covalent binding of drug to -COOH group of functionalized CNT and PEGylation of phospholipids showed that it is possible to control the size of malignant tumor (Kazemi-Beydokhti et al, 2014).…”

Section: Page 5 Of 22mentioning

confidence: 98%