Drug loading ability and release study of various size small mesoporous silica nanoparticle as drug carrier

Abstract

Mesoporous silica nanoparticles (MSN) have been widely developed as drug carriers for various drug models in various particle sizes. The morphology of MSN becomes one of the factors which influence drug loading ability. In this study, we investigated the correlation between particle size and surface charge toward the loading ability of MSN. We used various morphology of MSN included its zeta potential value and quercetin as a drug model. The result showed that both particle size and zeta potential value have a correlation toward loading ability. The smaller particle size has a higher loading ability. Meanwhile, the more negative surface charge has a higher loading ability. Additionally, we studied the drug release profile of MSN with different particle sizes. It showed that particle size and zeta potential value play important role in the drug release process to produce a typically-release profile.

Synthesis of cellulose nanocrystals from spinach waste for insulin delivery: comparison to chitosan nanoparticles

“…33 Increased values for the zeta-potential difference may represent drug loading. 34 The loading capacity for a drug can be influenced by the morphology of the drug carriers, including the particle size and zeta potential of nanoparticles. The interaction between medicinal compounds and nanoparticles can alter the zeta potential depending on drug loading on or in the nanoparticle.…”

Designing Covalent Organic Framework‐Based Light‐Driven Microswimmers toward Therapeutic Applications

“…While the positive zeta potential of the TABP‐PDA‐COF ( ζ TABP‐PDA‐COF = 12.13 ± 1.28 mV) reduces agglomeration and enables sufficient drug loading values, the negative zeta potential of the TpAzo‐COF ( ζ TpAzo‐COF = −19.67 ± 0.68 mV) reduces drug loading due to electrostatic repulsions. [ 38 ] In addition, a lower crystallinity and thereby, possibly decreased accessible pore volume of TpAzo‐COF are expected to lead to reduced DOX uptake. Overall, the DOX uptake of both COF materials is among the highest reported, also relative to other artificial structures using physical encapsulation.…”

Design of Chitosan-Coated, Quercetin-Loaded PLGA Nanoparticles for Enhanced PSMA-Specific Activity on LnCap Prostate Cancer Cells

“…Chu and co-workers [ 72 ] have described how nanofabrication techniques have hydrophobic drug loading limitations of approximately 10%, and a report by Lestari’s group [ 73 ] analyzed differently sized silica nanoparticles at drug loadings of 8.9% and 10%. They showed that there was a controlled, pH-dependent release of quercetin from the nanoparticle system, which is consistent with the results we observed.…”