Drug-loaded polymeric films as a promising tool for the treatment of periodontitis

Ghavami-Lahiji, Mehrsima; Shafiei, Farhad; Najafi, Farhood; Erfan, Mohammad

doi:10.1016/j.jddst.2019.04.034

Cited by 16 publications

(13 citation statements)

References 40 publications

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“…GLY belongs to the family of polysaccharides. In polymer chemistry, GLY is used as a plasticizer, because it can make the film soft, flexible, and elastic [ 27 , 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride

et al. 2021

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Currently, pharmaceutical companies are working on innovative methods, processes and products. Oral mucoadhesive systems, such as tablets, gels, and polymer films, are among these possible products. Oral mucoadhesive systems possess many advantages, including the possibility to be applied in swallowing problems. The present study focused on formulating buccal mucoadhesive polymer films and investigating the physical and physical–chemical properties of films. Sodium alginate (SA) and hydroxypropyl methylcellulose (HPMC) were used as film-forming agents, glycerol (GLY) was added as a plasticizer, and cetirizine dihydrochloride (CTZ) was used as an active pharmaceutical ingredient (API). The polymer films were prepared at room temperature with the solvent casting method by mixed two-level and three-level factorial designs. The thickness, tensile strength (hardness), mucoadhesivity, surface free energy (SFE), FTIR, and Raman spectra, as well as the dissolution of the prepared films, were investigated. The investigations showed that GLY can reduce the mucoadhesivity of films, and CTZ can increase the tensile strength of films. The distribution of CTZ proved to be homogeneous in the films. The API could dissolve completely from all the films. We can conclude that polymer films with 1% and 3% GLY concentrations are appropriate to be formulated for application on the buccal mucosa as a drug delivery system.

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“…GLY belongs to the family of polysaccharides. In polymer chemistry, GLY is used as a plasticizer, because it can make the film soft, flexible, and elastic [ 27 , 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride

et al. 2021

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“…The films showed good physicochemical properties, mucoadhesion, high drug loading capacity, and high ex vivo drug release after 12 h. The significant reduction in the bacterial count in a periodontitis model proved a potent anti-periodontitis activity. Another study reports the preparation and characterization of films based on PCL and alginic acid, loaded with metronidazole and doxycycline [ 63 ]. The mechanical properties (tensile strength) are affected by the presence of the drug, reducing with its concentration.…”

Section: Polymer–drug Systemsmentioning

confidence: 99%

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

et al. 2021

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Periodontal diseases are worldwide health problems that negatively affect the lifestyle of many people. The long-term effect of the classical treatments, including the mechanical removal of bacterial plaque, is not effective enough, causing the scientific world to find other alternatives. Polymer–drug systems, which have different forms of presentation, chosen depending on the nature of the disease, the mode of administration, the type of polymer used, etc., have become very promising. Hydrogels, for example (in the form of films, micro-/nanoparticles, implants, inserts, etc.), contain the drug included, encapsulated, or adsorbed on the surface. Biologically active compounds can also be associated directly with the polymer chains by covalent or ionic binding (polymer–drug conjugates). Not just any polymer can be used as a support for drug combination due to the constraints imposed by the fact that the system works inside the body. Biopolymers, especially polysaccharides and their derivatives and to a lesser extent proteins, are preferred for this purpose. This paper aims to review in detail the biopolymer–drug systems that have emerged in the last decade as alternatives to the classical treatment of periodontal disease.

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“…These technologies include chemical methods such as self-assembly; physical methods such as electrospinning, electrospraying, and 3D printing; and also the combination of these methods [38][39][40][41]. The drug-containing polymeric films are suggested as promising controlled release systems [42][43][44][45][46]. These films can be fabricated by solvent casting, solution casting, or extrusion.…”

Section: Introductionmentioning

confidence: 99%

A Novel Method for Preparation of Carrageenan/Fish Scale Collagen/Allopurinol Biocomposite Film

Nguyen

Dam

et al. 2021

International Journal of Polymer Science

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Biopolymers such as carrageenan or collagen can be used as carriers for loading a drug to enhance a drug’s bioavailability. In this work, allopurinol was loaded on a carrageenan/collagen blend and the carrageenan/collagen/allopurinol (CCA) biocomposite films were prepared using the ionic gelation method combined with the 3D printing method using carrageenan/collagen/allopurinol gel as a 3D printing ink material. The advantages of the 3D printing method are the ease in shaping the design of films and the ease in controlling the thickness of films. The results of infrared (IR) spectroscopy and field emission scanning electron microscopy (FESEM) analyses showed that the CCA biocomposite films have a regular structure, and the functional groups of components in the biocomposites can interact with each other. After 30 minutes of immersion in distilled water and pH buffer solution, the biocomposite films swelled and disintegrated. The carrageenan/collagen blend can control the release of allopurinol in simulated body fluids. In addition, the drug release kinetic models reflecting the release process of allopurinol from CCA biocomposite films in simulated body fluids have also been calculated.

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Drug-loaded polymeric films as a promising tool for the treatment of periodontitis

Cited by 16 publications

References 40 publications

Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride

Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

A Novel Method for Preparation of Carrageenan/Fish Scale Collagen/Allopurinol Biocomposite Film

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