Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy

Pei, Wenfeng; Cai, Ling; Gong, Xing; Zhang, Li; Zhang, Jiarong; Zhu, Ping; Jiang, Huijun; Wang, Chao; Wang, Shoulin; Chen, Jin

doi:10.1016/j.mtbio.2022.100272

Cited by 11 publications

(8 citation statements)

References 71 publications

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“…The inclusion of OA in the prepared NLC formulation may be the reason behind the observed hemolysis. This could be related to the liquid state of OA, which ruptures blood cells by altering the surface characteristics of erythrocytes (Pei et al, 2022). The obtained results agreed with the reported studies which showed that the addition of free fatty acids led to erythrocyte hemolysis (Hiremath et al, 2019; Tran et al, 2015; Wu et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

Assembly of nanostructured lipid carriers loaded gefitinib and simvastatin as hybrid therapy for metastatic breast cancer: Codelivery and repurposing approach

Sherif

Shahba

Nasr

et al. 2023

Drug Development Research

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Breast cancer represents a life‐threatening problem globally. The major challenge in the clinical setting is the management of cancer resistance and metastasis. Hybrid therapy can affect several cellular targets involved in carcinogenesis with a lessening of adverse effects. Therefore, the current study aims to assemble, and optimize a hybrid of gefitinib (GFT) and simvastatin (SIM)‐loaded nanostructured lipid carrier (GFT/SIM‐NLC) to combat metastatic and drug‐resistant breast cancer. GFT/SIM‐NLC cargos were prepared using design of experiments to investigate the impact of poloxamer‐188 and fatty acids concentrations on the physicochemical and pharmaceutical behavior properties of NLC. Additionally, the biosafety of the prepared GFT/SIM‐NLC was studied using a fresh blood sample. Afterward, the optimized formulation was subjected to an MTT assay to study the cytotoxic activity of GFT/SIM‐NLC compared to free GFT/SIM using an MCF‐7 cell line as a surrogate model for breast cancer. The present results revealed that the particle size of the prepared NLC ranged from (209 to 410 nm) with a negative zeta potential value ranging from (−17.2 to −23.9 mV). Moreover, the optimized GFT/SIM‐NLC formulation showed favorable physicochemical properties and promising lymphatic delivery cargos. A biosafety study indicates that the prepared NLC has a gentle effect on erythrocyte hemolysis. Cytotoxicity studies revealed that GFT/SIM‐NLC enhanced the killing of the MCF‐7 cell line compared to free GFT/SIM. This study concluded that the hybrid therapy of GFT/SIM‐NLC is a potential approach to combat metastatic and drug‐resistant breast cancer.

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Section: Resultsmentioning

confidence: 99%

Assembly of nanostructured lipid carriers loaded gefitinib and simvastatin as hybrid therapy for metastatic breast cancer: Codelivery and repurposing approach

Sherif

Shahba

Nasr

et al. 2023

Drug Development Research

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“…The assessment of mitochondrial membrane potential (△ψ m ) was carried out by a modified protocol based on a previous study . Briefly, HuH-7 cells were cultured onto laser confocal culture dishes with identical treatment as described above.…”

Section: Methodsmentioning

confidence: 99%

“…The assessment of mitochondrial membrane potential (△ψm) was carried out by a modified protocol based on a previous study. 26 Briefly, HuH-7 cells were cultured onto laser confocal culture dishes with identical treatment as described above. In addition, carbonyl cyanide m-chlorophenylhydrazone (CCCP) with a working concentration of 1 μM was utilized as a positive control to induce a decrease in mitochondrial membrane potential.…”

Section: Jc-1 Staining Analysismentioning

confidence: 99%

Astaxanthin Protects against Alcoholic Liver Injury via Regulating Mitochondrial Redox Balance and Calcium Homeostasis

Wang,

Zheng,

et al. 2023

J. Agric. Food Chem.

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“…BAMLET is an emerging nanotherapeutic, which comes out of conjugating bovine α-lactalbumin (BLA) with oleic acid and acts as apoptosis promoter. With this information in mind, Pei et al designed a nanosystem able to co-deliver a typical cytotoxic drug such as docetaxel (DTX) with BAMLET [ 117 ]. Their design was prepared from oleic acid modified MSNs, which upon loading with DTX and treatment with BLA, resulted in the formation of silica particles with a protein coating.…”

Section: Protein- and Peptide-based Therapeutics Employing Silica-bas...mentioning

confidence: 99%

Delivery of Therapeutic Biopolymers Employing Silica-Based Nanosystems

2023

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The use of nanoparticles is crucial for the development of a new generation of nanodevices for clinical applications. Silica-based nanoparticles can be tailored with a wide range of functional biopolymers with unique physicochemical properties thus providing several advantages: (1) limitation of interparticle interaction, (2) preservation of cargo and particle integrity, (3) reduction of immune response, (4) additional therapeutic effects and (5) cell targeting. Therefore, the engineering of advanced functional coatings is of utmost importance to enhance the biocompatibility of existing biomaterials. Herein we will focus on the most recent advances reported on the delivery and therapeutic use of silica-based nanoparticles containing biopolymers (proteins, nucleotides, and polysaccharides) with proven biological effects.

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Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy

Cited by 11 publications

References 71 publications

Assembly of nanostructured lipid carriers loaded gefitinib and simvastatin as hybrid therapy for metastatic breast cancer: Codelivery and repurposing approach

Assembly of nanostructured lipid carriers loaded gefitinib and simvastatin as hybrid therapy for metastatic breast cancer: Codelivery and repurposing approach

Astaxanthin Protects against Alcoholic Liver Injury via Regulating Mitochondrial Redox Balance and Calcium Homeostasis

Delivery of Therapeutic Biopolymers Employing Silica-Based Nanosystems

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