Drug loaded magnetic nanoparticles for cancer therapy

Jurgons, Roland; Seliger, Christian; Hilpert, Andrea; Trahms, Lutz; Odenbach, Stefan; Alexiou, Christoph

doi:10.1088/0953-8984/18/38/s24

Cited by 247 publications

(151 citation statements)

References 41 publications

Supporting

Mentioning

146

Contrasting

Unclassified

Order By: Relevance

“…12 Such measurements have been performed in vivo but with limited resolution and speed. 13 In 2005, magnetic particle imaging ͑MPI͒ was introduced as a means of producing 3D in vivo images of nanoparticle concentration.…”

Section: 2mentioning

confidence: 99%

Harmonic phase angle as a concentration‐independent measure of nanoparticle dynamics

Rauwerdink

Weaver

2010

Medical Physics

View full text Add to dashboard Cite

Purpose:The harmonic spectrum of magnetic nanoparticles contains valuable information about the quantity and environment of the particles. Harmonic amplitudes have been used to produce quantitative images and ratios of these amplitudes have been used to monitor changes in the particle environment. Harmonic phase angles have not yet been utilized in these pursuits. The authors explore harmonic phase angle as a concentration-independent means of remotely monitoring the dynamic magnetization of nanoparticles. Methods: A magnetic nanoparticle spectrometer was used to explore the impacts of viscosity and excitation frequency and amplitude on the phase angle of magnetization harmonics. A dynamic model, which accounts for particle relaxation times, was used to model some results. Results: Harmonic phase angle can undergo large changes when a nanoparticle's Brownian motion is altered. Excitation parameters and particle characteristics have a profound effect on the extent of these changes. Conclusions: Phase angle can allow for monitoring of various impacts on a nanoparticle's Brownian motion. When combined with other concentration-independent metrics, such as ratios of harmonic amplitudes, valuable information about the particle's environment can be gathered.

show abstract

Section: 2mentioning

confidence: 99%

Harmonic phase angle as a concentration‐independent measure of nanoparticle dynamics

Rauwerdink

Weaver

2010

Medical Physics

View full text Add to dashboard Cite

show abstract

“…[123][124][125][126] The concept of enhanced localization of drugs using this method may be envisioned, as magnetic particles have been coupled with pharmaceutical agents 124 and therapeutic radiolabeled molecules. 126 Imaging modalities have been used to activate an exogenous contrast nanostructure in vivo from outside the body.…”

Section: Iiid Evolution Of Multifunctional Cross-modal Nanostructurmentioning

confidence: 99%

Towards new functional nanostructures for medical imaging

Matsuura

Rowlands

2008

Medical Physics

View full text Add to dashboard Cite

Nanostructures represent a promising new type of contrast agent for clinical medical imaging modalities, including magnetic resonance imaging, x-ray computed tomography, ultrasound, and nuclear imaging. Currently, most nanostructures are simple, single-purpose imaging agents based on spherical constructs ͑e.g., liposomes, micelles, nanoemulsions, macromolecules, dendrimers, and solid nanoparticle structures͒. In the next decade, new clinical imaging nanostructures will be designed as multi-functional constructs, to both amplify imaging signals at disease sites and deliver localized therapy. Proposals for nanostructures to fulfill these new functions will be outlined. New functional nanostructures are expected to develop in five main directions: Modular nanostructures with additive functionality; cooperative nanostructures with synergistic functionality; nanostructures activated by their in vivo environment; nanostructures activated by sources outside the patient; and novel, nonspherical nanostructures and components. The development and clinical translation of next-generation nanostructures will be facilitated by a combination of improved clarity of the in vivo imaging and biological challenges and the requirements to successfully overcome them; development of standardized characterization and validation systems tailored for the preclinical assessment of nanostructure agents; and development of streamlined commercialization strategies and pipelines tailored for nanostructure-based agents for their efficient translation to the clinic.

show abstract

“…The core principle is that the vibrations of magnetic field is lin ked as per Faraday's law to induce a current which can then drive an electrical device [2]. Ferrofluids have attracting application in various fields like automobiles, electrical engineering [28,30,31,32], space technology, computer science, med ical imaging, bio med ical [3,4], targeted drug delivery [5,6], optical fiber [27,29] and sensors [7,8] etc. The temperature sensitivity issue on ferrofluid has already been studied [9,10].…”

Section: Introductionmentioning

confidence: 99%

Energy Conversion on Differential Magnetization of Fe3O4 Ferrofluid

Vaidya¹,

Pinjari²,

Holkar³

et al. 2017

IJERA

View full text Add to dashboard Cite

Ferrofluids are stable suspension of ferrimagnetic nanoparticles in hydrocarbon carrier. This flu id is used for harvesting energy using energy conversion device which is presented in this work. The device consists of two chambers, they are hot and cold chamber in which differential magnetization is lin ked with an inductor. Classically very small value of coupling coefficient |k| has been observed. System configuration shows an emf generation rate of about 44.4µV/K. Presented work shows another way of harvesting energy. Ferrofluid havin g a particle size o f 21n m was used in this case.

show abstract

Drug loaded magnetic nanoparticles for cancer therapy

Cited by 247 publications

References 41 publications

Harmonic phase angle as a concentration‐independent measure of nanoparticle dynamics

Harmonic phase angle as a concentration‐independent measure of nanoparticle dynamics

Towards new functional nanostructures for medical imaging

Energy Conversion on Differential Magnetization of Fe3O4 Ferrofluid

Contact Info

Product

Resources

About