Drug-loaded/grafted peptide-modified porous PEEK to promote bone tissue repair and eliminate bacteria

He, Xianhua; Deng, Yi; Yu, Yue; Lyu, Hao; Liao, Li

doi:10.1016/j.colsurfb.2019.06.038

Cited by 44 publications

(40 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CGA has antibacterial activities against Gram-negative and Gram-positive bacteria ( He et al, 2019 ). RNAseq profiling of various cell types infected with Salmonella has provided a treasure trove of lncRNAs that are regulated upon immune cell stimulation or pathogen invasion, but their molecular functions remain uncharacterized ( Garcia-Del Portillo and Pucciarelli, 2017 ; Yu et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Chlorogenic Acid Promotes Autophagy and Alleviates Salmonella Typhimurium Infection Through the lncRNAGAS5/miR-23a/PTEN Axis and the p38 MAPK Pathway

Tan

Fang

et al. 2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Background: Salmonella typhimurium (ST) causes several intestinal diseases. Polyphenols including chlorogenic acid (CGA) inhibit pathogenesis. Objective: This study aimed to investigate the mechanisms of CGA in ST infection. Methods: The intestinal pathological changes and survival rate of ST-infected mice were measured to verify the protection of CGA on ST infection. The antibacterial effects of CGA in vitro on the invasion to intestinal epithelial cells and autophagy was evaluated. The relationships among GAS5, miR-23a, and PTEN were verified. Expression of inflammation-and autophagy-related proteins was detected. Results: CGA treatment alleviated pathological damage, improved the secretion disturbance of intestinal cytokines caused by ST infection, and reduced the mortality of mice. Intestinal GAS5 was upregulated after CGA treatment. LncRNA GAS5 competitively bound to miR-23a to upregulate PTEN and inhibit the p38 MAPK pathway. CGA regulated the p38 MAPK pathway through lncRNA GAS5/miR-23a/PTEN axis to promote autophagy in ST infection. The functional rescue experiments of miR-23a and PTEN further identified these effects. Conclusion: CGA promotes autophagy and inhibits ST infection through the GAS5/miR-23a/PTEN axis and the p38 MAPK pathway.

show abstract

Section: Discussionmentioning

confidence: 99%

Chlorogenic Acid Promotes Autophagy and Alleviates Salmonella Typhimurium Infection Through the lncRNAGAS5/miR-23a/PTEN Axis and the p38 MAPK Pathway

Tan

Fang

et al. 2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…In contrast, osteoinductive growth factor (BFP) boosted osteoblast proliferation and differentiation. Hence the coating played a more significant part in antimicrobial bone regeneration ( He et al, 2019 ). In addition, grafting polyethylene glycol-arginine-glycine-aspartic acid polymer brushes on the titanium surface effectively inhibited the growth of Streptococcus mutans and Actinomyces naeslundii and promoted osteoblast adhesion ( Liu et al, 2016 ).…”

Section: Antibacterial-osteogenic Modifications Of Dental Implant Sur...mentioning

confidence: 99%

Advances and Prospects in Antibacterial-Osteogenic Multifunctional Dental Implant Surface

Wang

Cai

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

In recent years, dental implantation has become the preferred protocol for restoring dentition defects. Being the direct contact between implant and bone interface, osseointegration is the basis for implant exerting physiological functions. Nevertheless, biological complications such as insufficient bone volume, poor osseointegration, and postoperative infection can lead to implant failure. Emerging antibacterial-osteogenic multifunctional implant surfaces were designed to make up for these shortcomings both during the stage of forming osseointegration and in the long term of supporting the superstructure. In this mini-review, we summarized the recent antibacterial-osteogenic modifications of the dental implant surface. The effects of these modifications on biological performance like soft tissue integration, bone osteogenesis, and immune response were discussed. In addition, the clinical findings and prospects of emerging antibacterial-osteogenic implant materials were also discussed.

show abstract

“…Strategies are summarized and illustrated at Figure 2 and are listed as follows: PEEK sulfonation process, which can be employed either to produce a 3D network on polymer surface [ 39 ], or to embed therapeutic compounds (e.g., lactams [ 45 , 46 ], mouse beta-defensin [ 59 ]). Further surface treatments were also employed after the sulfonation process, such as chlorogenic acid/grafting peptide [ 43 ], graphene oxide coating [ 61 ] and hydrothermal treatment [ 48 ]. Incorporation of therapeutic and/or bioactive agents in the PEEK matrix or on the PEEK surface, such as simvastatin-PLLA [ 39 ]; Ag and Zn ions [ 37 , 39 , 40 , 58 ], dexamethasone plus minocycline-loaded liposomes [ 57 ], bioactive titanium dioxide (TiO 2 ) [ 52 ], 2-methacryloyloxyethyl phosphorylcholine [ 51 ] and titanium plasma [ 56 ].…”

Section: Strategies To Reduce Biofilm Formation In Peek Materials mentioning

confidence: 99%

“…PEEK sulfonation process, which can be employed either to produce a 3D network on polymer surface [ 39 ], or to embed therapeutic compounds (e.g., lactams [ 45 , 46 ], mouse beta-defensin [ 59 ]). Further surface treatments were also employed after the sulfonation process, such as chlorogenic acid/grafting peptide [ 43 ], graphene oxide coating [ 61 ] and hydrothermal treatment [ 48 ].…”

Section: Strategies To Reduce Biofilm Formation In Peek Materials mentioning

confidence: 99%

Strategies to Reduce Biofilm Formation in PEEK Materials Applied to Implant Dentistry—A Comprehensive Review

et al. 2020

View full text Add to dashboard Cite

Polyether-ether-ketone (PEEK) has emerged in Implant Dentistry with a series of short-time applications and as a promising material to substitute definitive dental implants. Several strategies have been investigated to diminish biofilm formation on the PEEK surface aiming to decrease the possibility of related infections. Therefore, a comprehensive review was carried out in order to compare PEEK with materials widely used nowadays in Implant Dentistry, such as titanium and zirconia, placing emphasis on studies investigating its ability to grant or prevent biofilm formation. Most studies failed to reveal significant antimicrobial activity in pure PEEK, while several studies described new strategies to reduce biofilm formation and bacterial colonization on this material. Those include the PEEK sulfonation process, incorporation of therapeutic and bioactive agents in PEEK matrix or on PEEK surface, PEEK coatings and incorporation of reinforcement agents, in order to produce nanocomposites or blends. The two most analyzed surface properties were contact angle and roughness, while the most studied bacteria were Escherichia coli and Staphylococcus aureus. Despite PEEK’s susceptibility to biofilm formation, a great number of strategies discussed in this study were able to improve its antibiofilm and antimicrobial properties.

show abstract

Drug-loaded/grafted peptide-modified porous PEEK to promote bone tissue repair and eliminate bacteria

Cited by 44 publications

References 33 publications

Chlorogenic Acid Promotes Autophagy and Alleviates Salmonella Typhimurium Infection Through the lncRNAGAS5/miR-23a/PTEN Axis and the p38 MAPK Pathway

Chlorogenic Acid Promotes Autophagy and Alleviates Salmonella Typhimurium Infection Through the lncRNAGAS5/miR-23a/PTEN Axis and the p38 MAPK Pathway

Advances and Prospects in Antibacterial-Osteogenic Multifunctional Dental Implant Surface

Strategies to Reduce Biofilm Formation in PEEK Materials Applied to Implant Dentistry—A Comprehensive Review

Contact Info

Product

Resources

About