Drug-loaded cubic micro-chamber made of a biodegradable polymer for bacteria-based drug delivery

Yoo, Hyun Jung; Lee, Sangmin; Ahn, Jae Hyun; Cho, Dong‐il Dan

doi:10.1109/nems.2013.6559923

Cited by 5 publications

(6 citation statements)

References 15 publications

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“…A mesh and roller are used to spread pulverized Lapatinib uniformly onto the PCL film. After the lamination process [18] using the pulverized Lapatinib loaded PCL film and another PCL film [7], pulverized Lapatinib IS successfully encapsulated between two PCL films.…”

Section: Screen Printing Methodsmentioning

confidence: 99%

“…Fig. I is a schematic illustration of the x-ray lithography process in PAL [7]. In this process, accelerated electrons from a linear accelerator are injected into a storage ring which is consists of bending magnets.…”

Section: X-ray Lithographymentioning

confidence: 99%

“…While bending magnets hold the accelerated electrons in the storage ring, accelerated electrons generate the high energy of the x-ray synchrotron radiation. Because the x-ray synchrotron radiation has a vertically narrow and horizontally wide spot size, a controllable scanning system is used for the x-ray lithography in PAL [7][8]. The x-ray mask plays an important role in the x-ray lithography because the patterns determine the exposed area.…”

Section: X-ray Lithographymentioning

confidence: 99%

“…To maintain the therapeutic level by the time controlled release from DDS, biodegradable polymers, such as poly (lactic-co-glycolic acid) (PLGA), poly (lactic acid) (PLA), and PCL, have been used and widely investigated as a carrier of DDS. Our previous study has presented a novel method for biodegradable polymer micromachining using the x-ray lithography process [7][8].…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of biodegradable polymeric micro chambers encapsulated with pulverized drug for bacteria-based microrobots

Song

Yoo

Jeong

et al. 2014

2014 14th International Conference on Control, Automation and Systems (ICCAS 2014)

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This paper presents a method of fabricating pulverized drug, Lapatinib (Tykerb®), loaded micro chambers made of a biodegradable polymer, poly (£-caprolactone) (PCL), for bacteria-based microrobots. The PCL is a biodegradable, biocompatible polymer which is approved by the U.S. Food and Drug Administration (FDA) for use in the implantable medical devices. Lapatinib is approved by the U.S. FDA for the treatment of advanced or metastatic breast cancer. In order to realize bacteria-based microrobots, selective bacterial adhesion is necessary which can enhance directional locomotion of the bacteria-based microrobots. The x-ray lithography process can be used for biodegradable polymer micromachining to fabricate structures with various shapes which can be applied for bacteria-based microrobots. A pulverized drug is used because a liquefied drug cannot be used for the x-ray lithography process. To fabricate pulverized Lapatinib loaded micro chambers, the PCL films are prepared by the solvent casting method and lamination process. Lapatinib is encapsulated between the PCL films by the screen printing method. The x-ray lithography process is then used for fabrication of micro chambers. The fabrication results indicate that the proposed method is appropriate for fabrication of biodegradable polymeric micro chambers encapsulated with the pulverized drug for bacteria-based microrobots.

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Section: Screen Printing Methodsmentioning

confidence: 99%

Section: X-ray Lithographymentioning

confidence: 99%

Section: X-ray Lithographymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fabrication of biodegradable polymeric micro chambers encapsulated with pulverized drug for bacteria-based microrobots

Song

Yoo

Jeong

et al. 2014

2014 14th International Conference on Control, Automation and Systems (ICCAS 2014)

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“…First, a PCL film which has a thickness of 50 μm is prepared by a spin coating process and a lamination process [30]. Next, X-ray synchrotron irradiation is performed to pattern 50 μm × 50 μm squares.…”

Section: Biodegradable Polymeric Microstructuresmentioning

confidence: 99%

Motility Control of Bacteria-Actuated Biodegradable Polymeric Microstructures by Selective Adhesion Methods

2014

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Certain bacteria have motility and can be made non-toxic, and using them for drug delivery has been proposed. For example, using bacteria with flagella motion in multiple spin actuators in drug delivery microrobots has been suggested. This paper investigates various adhesion enhancement methods for attaching bacteria on preferred surfaces of cubic polymeric microstructures to achieve the directional control of motion. Serratia marcescens which has an excellent swimming behavior and 50-μm sized cubic structures made of biodegradable poly-capro-lactone (PCL) are used. Three treatment methods are investigated and compared to the untreated control case. The first method is retarding bacterial attachments by coating certain surfaces with bovine serum albumin (BSA) which makes those surfaces anti-adherent to bacteria. The second and third methods are roughening the surfaces with X-ray irradiation and plasma respectively to purposely increase bacterial attachments on the roughened surfaces. The measured motilities of bacteria-tethered PCL microactuators are 1.40 μm/s for the BSA coating method, 0.82 μm/s for the X-ray irradiation, and 3.89 μm/s for the plasma treatment method. Therefore, among the methods investigated in the paper the plasma treatment method achieves the highest directionality control of bacteria motility. OPEN ACCESSMicromachines 2014, 5 1288

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Medical Applications

2021

Polymers and Additives in Extreme Environments

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Drug-loaded cubic micro-chamber made of a biodegradable polymer for bacteria-based drug delivery

Cited by 5 publications

References 15 publications

Fabrication of biodegradable polymeric micro chambers encapsulated with pulverized drug for bacteria-based microrobots

Fabrication of biodegradable polymeric micro chambers encapsulated with pulverized drug for bacteria-based microrobots

Motility Control of Bacteria-Actuated Biodegradable Polymeric Microstructures by Selective Adhesion Methods

Medical Applications

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