Drug intolerance reaction to insulin therapy caused by metacresol

Clerx, V.; Keybus, C. Van den; Kochuyt, Anne-Marie; Goossens, An

doi:10.1034/j.1600-0536.2003.00034.x

Cited by 23 publications

(15 citation statements)

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“…The change to lispro insulin as a less allergenic substance, insulin desensitization or the usage of insulin pumps may be useful in the treatment of insulin allergy 106–108 . Rare adverse cutaneous reactions have been reported to metacresol (m‐methyl phenol), a preservative contained in almost all commercially available insulins 109 . The rare systemic type I IgE‐mediated hypersensitivity reaction to insulin may lead to life‐threatening anaphylaxis in worst case and should be kept in mind 110…”

Section: Skin Complications Due To Therapy Of Diabetesmentioning

confidence: 99%

“…[106][107][108] Rare adverse cutaneous reactions have been reported to metacresol (m-methyl phenol), a preservative contained in almost all commercially available insulins. 109 The rare systemic type I IgE-mediated hypersensitivity reaction to insulin may lead to life-threatening anaphylaxis in worst case and should be kept in mind. 110…”

Section: Cutaneous Reactions To Insulinmentioning

confidence: 99%

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Skin signs in diabetes mellitus

Behm

Schreml

Landthaler

et al. 2012

Acad Dermatol Venereol

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Diabetes mellitus is the most common endocrine disorder with continuously increasing prevalence. Blood vessels, nerves, eyes, kidneys and skin are affected, which causes both an enormous financial burden and a reduced quality of life of the affected patients. Long-standing diabetes may impair skin homeostasis resulting in skin manifestations in at least one third of all diabetics. The skin involvement may be the first presenting sign of diabetes, thus the respective skin signs should lead to diabetes focused diagnostic. Besides, the skin signs may be considered as a marker for the course of the disease or for the success of therapeutic interventions.

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Section: Skin Complications Due To Therapy Of Diabetesmentioning

confidence: 99%

Section: Cutaneous Reactions To Insulinmentioning

confidence: 99%

Skin signs in diabetes mellitus

Behm

Schreml

Landthaler

et al. 2012

Acad Dermatol Venereol

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“…Allergy to the metacresol in insulin has been described previously in an adult with T1DM [8]. Because metacresol is universally present in all current insulin preparations, we believe it has been overlooked as a possible cause of insulin allergy in some past case reports.…”

Section: Discussionmentioning

confidence: 84%

Successful management of allergy to the insulin excipient metacresol in a child with type 1 diabetes: a case report

Wheeler

Taylor

2012

J Med Case Reports

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IntroductionInsulin allergy to human insulin preparations during the treatment of diabetes is suggested to occur at rates ranging from <1.0% to 2.4%. These reactions vary from mild localized reactions, which resolve with repeated exposure, to life-threatening anaphylaxis and death. The management of persistent insulin allergy in type 1 diabetes mellitus is particularly complicated because ongoing treatment with insulin is essential.Case presentationWe present the case of a 12-year-old Caucasian girl with localized allergy to the insulin excipient metacresol, and the subsequent desensitization therapy using continuous subcutaneous insulin infusion with simultaneous intravenous insulin infusion.ConclusionsThis is the first documented case of allergy to the metacresol component of insulin in the pediatric type 1 diabetes literature. We describe an approach to diagnosis and management of metacresol allergy in type 1 diabetes.

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“…Crossreactivity is described between different low-molecular-weight methyl phenols. 4,5 False-positive tests are possible, as metacresol is known to be an irritant.…”

Section: Discussionmentioning

confidence: 99%

Allergy to metacresol in a type 2 diabetes patient

2020

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K E Y W O R D S : allergy, case report, diabetes, insulin, metacresol Since the introduction of human insulin, the incidence of allergic reactions has decreased from 50% to 1%-2.4%. 1 The culprit may be insulin or an excipient. | CASE REPORTA 79-year-old woman presented with erythematous papules on the abdomen following the injections of biosynthetic insulin (Humuline; Eli Lilly, Brussels), spontaneously resolving after 3 days. Her treatment consisted of regular insulin with long-acting protamine-coupled insulin (Humuline 30/70). She reported previous urticaria and angioedema with sea food and amoxicillin + clavulanic acid.Allergy test results are summarized in Table 1. Skin biopsies of an abdominal lesion and a positive prick test to 10 −3 diluted metacresol showed superficial and deep perivascular infiltration of lymphocytes, neutrophils, and eosinophils. Skin contact allergy associated with immediate reaction to metacresol was diagnosed. The allergic symptoms did not recur using a metacresol-free insulin (Implantable Insuman; Sanofi) used in insulin pumps or in intraperitoneal insulin release devices (Figure 1). 316COLSON ET AL.

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Drug intolerance reaction to insulin therapy caused by metacresol

Cited by 23 publications

References 0 publications

Skin signs in diabetes mellitus

Skin signs in diabetes mellitus

Successful management of allergy to the insulin excipient metacresol in a child with type 1 diabetes: a case report

Allergy to metacresol in a type 2 diabetes patient

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