Drug interactions between hormonal contraceptives and psychotropic drugs: a systematic review

Drug interactions between rifamycin antibiotics and hormonal contraception: a systematic review

“…For cohort and case‐control studies, we graded each of the following criteria: definition and assessment of exposures, definition and identification of outcomes, selection of controls, blinding, confounders, sample size, response rate/follow up, and internal validity . As no standardised grading scale exists to assess the quality of PK studies, we utilised a rating system previously reported to evaluate studies with PK outcomes, which included assessment of study design, sample size, exposures, outcomes, timing, intersubject variability, population, steady state of perpetrator drug, and validation of assays . We graded studies based on their primary outcome, but also report secondary outcomes.…”

“…11 As no standardised grading scale exists to assess the quality of PK studies, we utilised a rating system previously reported to evaluate studies with PK outcomes, which included assessment of study design, sample size, exposures, outcomes, timing, intersubject variability, population, steady state of perpetrator drug, and validation of assays. 12 We graded studies based on their primary outcome, but also report secondary outcomes. A study received the overall grade of good if every graded component received a score of good, and poor if one or more grading criteria was graded as poor (considered a fatal flaw that would invalidate results).…”

Drug interactions between non-rifamycin antibiotics and hormonal contraception: a systematic review

“…For trials with pharmacokinetic outcomes, we used a previously reported quality rating system to assess study design, sample size, drug exposure and adherence, appropriateness of pharmacokinetic parameters, timing of blood draws, intersubject variability, steady state of perpetrator drug, and validation of assays. 9 The quality of each study was assigned independently by 2 authors. Any differences were resolved through discussion with a third author.…”

CE: An Evidence-Based Update on Contraception

“…SSRIs 1 Evidence: Limited clinical and pharmacokinetic data do not demonstrate concern for SSRIs decreasing the effectiveness of oral contraceptives. Limited evidence suggests that for women taking SSRIs, the use of hormonal contraceptives was not associated with differences in effectiveness of the SSRI for treatment or in adverse events when compared with women not taking hormonal contraceptives (379).…”