1975
DOI: 10.1042/bj1500259
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Drug induction and sex differences of renal glutathione S-transferases in the rat

Abstract: Treatment of male rats with 3,4-benzopyrene, 3-methylcholanthrene and phenobarbital resulted in the induction of glutathione S-aryl- and S-aralkyl-transferase activities in kidney cytosol. Benzopyrene produced 77 and 44% increases in aryl and aralkyl activities respectively. Methylcholanthrene caused 73 and 86% increases in the retrospective activities, whereas phenobarbital treatment increased only aralkyl activity (51%). There was no effect on epoxide or alkyl glutathione S-transferase activities with these … Show more

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Cited by 43 publications
(13 citation statements)
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“…It is likely that further studies on the renal transferases may reveal similar changes as a function of some of these parameters (Clifton et al, 1975;Kaplowitz & Clifton, 1976;Kirsch et al, 1975). Differences in the amino acid composition between most of the purified rat transferases suggest that at least some represent separate gene products .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…It is likely that further studies on the renal transferases may reveal similar changes as a function of some of these parameters (Clifton et al, 1975;Kaplowitz & Clifton, 1976;Kirsch et al, 1975). Differences in the amino acid composition between most of the purified rat transferases suggest that at least some represent separate gene products .…”
Section: Discussionmentioning
confidence: 99%
“…Further, differences in substrate specificity suggest that the composition (identity and/or proportion) of the transferases depends also on tissue. Renal and hepatic cytosol exhibit major' differences in transferase substrate specificity (Clifton et al, 1975;Kaplowitz & Clifton, 1976;Kaplowitz et al, 1976 …”
mentioning
confidence: 99%
“…However, renal glutathione S-transferase activities are higher for several substrates in female than male rats (Clifton et al 1975), and therefore neither hypothesis explains the variability in sex-related response to different nephrotoxic xenobiotics. Only a hypothetical difference in xenobiotic-related metabolism could explain these discrepancies.…”
Section: Sex Differencesmentioning
confidence: 93%
“…For instance, the enzyme had higher activity in male than in female rats with a variety of substrates [7,8], thus underlining significant gender-related differences [9]. On the contrary, renal GST activities were higher with several substrates in female than in male rats [10] and sex differences were found also in isophorms of rat and human enzyme [11]. In addition, the half-life of renal reduced glutathione (GSH) is shorter in male (29 minutes) than in female (57 minutes) mouse [12].…”
Section: Introductionmentioning
confidence: 93%