Drug-Induced Tinnitus and Other Hearing Disorders

Seligmann, H; Podoshin, L; Ben‐David, Jacob; Fradis, Milo; Goldsher, Moshe

doi:10.2165/00002018-199614030-00006

Cited by 119 publications

(98 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Seligmann et al (1996) listed more than 130 drugs and chemicals reported to be potentially ototoxic, with the major classes of known ototoxic compounds being the aminoglycosides and other antimicrobials, anti-inflammatory agents, diuretics, antimalarial drugs, antineoplastic agents, and some topically administered agents. Most of these drugs were initially recognized as being ototoxic after anecdotal reports of hearing loss, tinnitus, or balance impairment.…”

Section: Introductionmentioning

confidence: 99%

Using the Zebrafish Lateral Line to Screen for Ototoxicity

Chiu

Cunningham

Raible

et al. 2008

JARO

178

134

View full text Add to dashboard Cite

The zebrafish is a valuable model for studying hair cell development, structure, genetics, and behavior. Zebrafish and other aquatic vertebrates have hair cells on their body surface organized into a sensory system called the lateral line. These hair cells are highly accessible and easily visualized using fluorescent dyes. Morphological and functional similarities to mammalian hair cells of the inner ear make the zebrafish a powerful preparation for studying hair cell toxicity. The ototoxic potential of drugs has historically been uncovered by anecdotal reports that have led to more formal investigation. Currently, no standard screen for ototoxicity exists in drug development. Thus, for the vast majority of Food and Drug Association (FDA)-approved drugs, the ototoxic potential remains unknown. In this study, we used 5-day-old zebrafish larvae to screen a library of 1,040 FDA-approved drugs and bioactives (NINDS Custom Collection II) for ototoxic effects in hair cells of the lateral line. Hair cell nuclei were selectively labeled using a fluorescent vital dye. For the initial screen, fish were exposed to drugs from the library at a 100-μM concentration for 1 h in 96-well tissue culture plates. Hair cell viability was assessed in vivo using fluorescence microscopy. One thousand forty drugs were rapidly screened for ototoxic effects. Seven known ototoxic drugs included in the library, including neomycin and cisplatin, were positively identified using these methods, as proof of concept.Fourteen compounds without previously known ototoxicity were discovered to be selectively toxic to hair cells. Dose-response curves for all 21 ototoxic compounds were determined by quantifying hair cell survival as a function of drug concentration. Dose-response relationships in the mammalian inner ear for two of the compounds without known ototoxicity, pentamidine isethionate and propantheline bromide, were then examined using in vitro preparations of the adult mouse utricle. Significant dose-dependent hair cell loss in the mouse utricle was demonstrated for both compounds. This study represents an important step in validating the use of the zebrafish lateral line as a screening tool for the identification of potentially ototoxic drugs.

show abstract

Section: Introductionmentioning

confidence: 99%

Using the Zebrafish Lateral Line to Screen for Ototoxicity

Chiu

Cunningham

Raible

et al. 2008

JARO

178

134

View full text Add to dashboard Cite

show abstract

“…Lormetazepam's 10-hour elimination half-life makes any withdrawal phenomenon between 2 drug administrations unlikely. An interesting element is the qualitative change in the hallucination with the introduction of amitriptyline, because tinnitus is reported by about 1% of patients receiving tricyclic antidepressants (11). The continued symptoms after the drugs were stopped could suggest that some undetected predisposing oto-neurologic factors facilitated the appearance of the hallucination François Curtin, MD, MPhil Charles Remund, MD Geneva, Switzerland…”

mentioning

confidence: 99%

Bupropion-Methylphenidate Combination and Grand Mal Seizures

Ickowicz

2002

Can J Psychiatry

View full text Add to dashboard Cite

“…These agents may damage the cochleae and may cause vertigo, tinnitus, and hearing loss. Ototoxicity due to cisplatin has been reported in 10%-70% of adults (6,7). In a study by Reddel et al (8), ototoxicity was detected in 72% of adult patients treated with cisplatin.…”

Section: Discussionmentioning

confidence: 99%