Drug-induced red cell dyscrasias

Ammus, Sharhabil S.; Yunis, Adel A.

doi:10.1016/0268-960x(89)90001-5

Cited by 21 publications

(12 citation statements)

References 146 publications

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“…Furthermore, the dose-related, toxic sideroblastic anemia associated with the antibiotic chloramphenicol may be related to its mechanism of action; chloramphenicol is an inhibitor of bacterial ribosomal translation, and mammalian mitochondrial ribosomes are more closely structurally related to bacterial ribosomes than to their mammalian cytosolic counterparts. 35 MLASA due to mutations in PUS1 or YARS2…”

Section: Pmpsmentioning

confidence: 99%

Congenital Sideroblastic Anemias: Iron and Heme Lost in Mitochondrial Translation

Fleming

2011

Hematology

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The congenital sideroblastic anemias (CSAs) are an uncommon, diverse class of inherited hematopoietic disorders characterized by pathological deposition of iron in the mitochondria of erythroid precursors. In recent years, the genetic causes of several clinically distinctive forms of CSA have been elucidated, which has revealed common themes in their pathogenesis. In particular, most, if not all, can be attributed to disordered mitochondrial heme synthesis, iron-sulfur cluster biogenesis, or pathways related to mitochondrial protein synthesis. This review summarizes the clinical features, molecular genetics, and pathophysiology of each of the CSAs in the context of these pathways.

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Section: Pmpsmentioning

confidence: 99%

Congenital Sideroblastic Anemias: Iron and Heme Lost in Mitochondrial Translation

Fleming

2011

Hematology

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“…The ethanol-induced membrane damage leads to an accumulation of iron in mitochondria [7,8,[19][20][21] with the formation of ring sideroblasts (found in 14% of our series). As already mentioned, mitochondrial iron is, in contrast to lysosomal iron, not resistant to decalcification and, therefore, only visible in the bone marrow smears [18], Further abnormal iron deposition was found in plas ma cells, as we observed in 18% of our series.…”

Section: Discussionmentioning

confidence: 99%

Alcoholic Dyshaematopoiesis: Morphological Features of Alcohol-Induced Bone Marrow Damage in Biopsy Sections Compared with Aspiration Smears

Budde¹,

Hellerich²

1995

Acta Haematol

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We investigated trephine biopsies from 118 alcoholic patients in order to establish whether or not the known alcohol-induced alterations seen in smears are seen in bone marrow tissue sections, and whether new features might emerge, which could be suitable for defining the histological picture of a condition to be known as ‘alcoholic dyshaematopoiesis’. The main changes involve erythropoiesis and iron metabolism. They can be attributed in part to destabilization of the red cell membrane. While these alterations are clearly visible in tissue sections, aspiration smears are needed to detect other features, especially ring sideroblasts.

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“…A large number of drugs that cause alterations on the shape and physiology of the red cells have been cited by some authors [14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Cellular effects of an aqueous solution of Losartan® on the survival of Escherichia coli AB1157 in the presence and absence of SnCl2, and on the physiological property (osmotic fragility) of the erytrocyte

Zaidan¹,

Matos²,

Machado³

et al. 2010

ABB

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The angiotensin receptors type 1 (AT1) have affinity by Losartan®, low affinity to non-peptides antagonists and similar effect as Angiotensin-convert-enzyme inhibitors. It have been reported that natural and synthetic products might reduce the genotoxic and cytotoxic effects related to stannous chloride (SnCl2). SnCl2 is used in nuclear medicine as a reducing agent to obtain technetium-99 m-radiopharmaceuticals. The aim of this work was to evaluate the cellular effects produced by a solution of Losartan® (25 mg/ml) on the survival of Escherichia coli AB1157 in the presence and absence of SnCl2, and on the osmotic fragility of erythrocytes of the blood of Wistar rats. Briefly, blood sample was withdrawn by Wistar rats with heparinized syringe and incubated with Losartan® solution. Saline (NaCL 0.9%) was used as a control. The samples were gently mixed with hypotonic solutions of NaCl. After that it was centrifuged and the supernadant isolated for optical determination of the hemoglobin present. E. coli AB1157 cultures (exponential growth phase) were collected by centrifugation, washed and resuspended in 0.9% NaCl. Samples were incubated in water bath shaker with: (a) SnCl2 (25 μg/ml), (b) Losartan® (25 mg/ml) and (c) SnCl2 (25 μg/ml) + Losartan® (25 mg/ml). Incubation with 0.9% NaCl was also carried out (control). At 60 min intervals, aliquots were withdrawn, diluted, spread onto Petri dishes with solid LB medium and incubated overnight. The colonies formed were counted and the survival fractions calculated. Statistical analysis was performed. The results showed that there was a significantly increase (P < 0.05) in the osmotic fragility of the blood cells treated with Losartan®. Moreover, Losartan® was also able to protect the E. coli cultures against the lesive action of SnCl2. Although, in erythrocyte the osmotic fragility was increased by the presence of Losartan® that could 1) alter the physical properties of this cell, or 2) had a direct or indirect effect on the intracellular sodium concentration or 3) had acted on the cardiovascular system. It suggested that the Losartan® did interfere strongly with cellular metabolism and did alter the survival fractions of E. coli AB1157.

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Drug-induced red cell dyscrasias

Cited by 21 publications

References 146 publications

Congenital Sideroblastic Anemias: Iron and Heme Lost in Mitochondrial Translation

Congenital Sideroblastic Anemias: Iron and Heme Lost in Mitochondrial Translation

Alcoholic Dyshaematopoiesis: Morphological Features of Alcohol-Induced Bone Marrow Damage in Biopsy Sections Compared with Aspiration Smears

Cellular effects of an aqueous solution of Losartan® on the survival of Escherichia coli AB1157 in the presence and absence of SnCl2, and on the physiological property (osmotic fragility) of the erytrocyte

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Drug-induced red cell dyscrasias

Cited by 21 publications

References 146 publications

Congenital Sideroblastic Anemias: Iron and Heme Lost in Mitochondrial Translation

Congenital Sideroblastic Anemias: Iron and Heme Lost in Mitochondrial Translation

Alcoholic Dyshaematopoiesis: Morphological Features of Alcohol-Induced Bone Marrow Damage in Biopsy Sections Compared with Aspiration Smears

Cellular effects of an aqueous solution of Losartan&#174; on the survival of Escherichia coli AB1157 in the presence and absence of SnCl2, and on the physiological property (osmotic fragility) of the erytrocyte

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Cellular effects of an aqueous solution of Losartan® on the survival of Escherichia coli AB1157 in the presence and absence of SnCl2, and on the physiological property (osmotic fragility) of the erytrocyte