Drug-induced Pulmonary Disorders

Lee‐Chiong, Teofilo; Zitnik, Ralph; Matthay, Richard A.

doi:10.1007/978-1-4471-3440-4_19

Cited by 3 publications

(1 citation statement)

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“…Drug-induced pulmonary toxicities may be categorized as chronic fibrosis, noncardiogenic pulmonary edema, or hypersensitivity disease. 21 Bleomycin produces chronic fibrosis. 22 Patients present with progressive dyspnea in the setting of high cumulative doses of bleomycin.…”

Section: Discussionmentioning

confidence: 99%

Severe interstitial pneumonitis associated with docetaxel administration

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Mortimer

Picus

2002

Cancer

109

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BACKGROUNDInterstitial pneumonitis has not been reported as a toxicity of docetaxel. The authors report the presentation and natural history of four patients who developed a severe interstitial pneumonitis after receiving docetaxel.METHODSThe hospital and outpatient records of patients treated with docetaxel were reviewed to identify whether any of these patients required an evaluation for respiratory problems.RESULTSFour patients developed an interstitial pneumonitis that could be explained only as a toxicity of docetaxel. None had metastatic disease to the lung, and all had normal liver function before receiving chemotherapy. The patients presented with acute dyspnea and fever within 1–2 weeks of receiving docetaxel. All developed progressive interstitial infiltrates and respiratory failure that required mechanical ventilation. An exhaustive workup for other causes of pneumonitis was negative. Broad‐spectrum antibiotics and corticosteroids were ineffective. Two patients died of complications related to the pulmonary process. The two survivors required ventilatory support for more than 21 days. The clinical and pathologic findings of these patients are presented.CONCLUSIONSInterstitial pneumonitis is a rare and potentially fatal complication of docetaxel treatment. Prolonged ventilatory support is appropriate in patients with a favorable prognosis. Cancer 2002;94:847–53. © 2002 American Cancer Society.DOI 10.1002/cncr.10263

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Section: Discussionmentioning

confidence: 99%