Drug-Induced Pseudolymphoma and Hypersensitivity Syndrome

Drug-induced hypersensitivity syndrome due to cyanamide associated with multiple reactivation of human herpesviruses

“…Hypogammaglobulinaemia associated with DIHS has been reported [Callot et al, 1996;Descamps et al, 2001;Aihara et al, 2003], although it is known that anticonvulsants, the major causal drugs of DIHS, sometimes induce hypogammaglobulinaemia even without symptoms of DIHS. In this patient, it seems that drugs did not induce the low level of IgG because it continued over half a year after withdrawal of the causal drugs.…”

“…This syndrome develops within 2-6 weeks after taking the causal drug, and tends to be prolonged for 2 weeks to several months after its discontinuation. The major causal drugs reported are anticonvulsants [Callot et al, 1996;Carroll et al, 2001;Descamps et al, 2001;Aihara et al, 2004], allopurinol [Suzuki et al, 1998], sulfasalazine [Tohyama et al, 1998], dapsone [Callot et al, 1996;Carroll et al, 2001], minocycline [Callot et al, 1996;Carroll et al, 2001], and mexiletine chloride [Callot et al, 1996;Mitani et al, 2003]. No case induced by cyanamide has been reported.…”

DRESS syndrome: a case report and literature review

“…Its incidence ranges between 1 in 1000 and 1 in 10 000 exposures. The aromatic anticonvulsants (phenytoin, phenobarbital, carbamazepine) and sulphonamides are the most common drugs described in this syndrome, but a variety of other drugs have been associated such as dapsone, allopurinol, captopril, calcium- channel blockers, ranitidine, thalidomide, minocicline, sulfasalazine, non-steroidal anti-inflammatory drugs, tuberculostatics, α-metildope and antiretroviral drugs (zalcitabine, neviparine) 2–4. The onset of the disease usually ranges from 2 to 6 weeks after the initiation of the therapy 5.…”

“…The liver is the most common affected organ in DRESS syndrome. The findings may range from a transitory increase in liver enzymes to liver necrosis with fulminant hepatic failure, that is thought to be mediated by infiltration of eosinophils, resulting in death or liver transplantation 2–4. These last two features are more frequently seen in women between the second and fourth decade of life with the outcome being independent of the use or dose of immunosuppressive therapy.…”

An infant with γ-globulin-induced hypersensitivity syndrome who developed Evans' syndrome after a second γ-globulin treatment

“…[1][2][3] Carbamazepine, sodium valproate, ethosuximide, sulfasalazine, allopurinol, and ibuprofen have been implicated in occurrences of this disease. 1,2 A clinical resemblance to infectious mononucleosis suggests that an underlying viral infection might be involved in triggering the pathophysiological abnormalities underlying these reactions.…”