Drug-Induced Parkinsonism

Shin, Hae Won; Chung, Sun Ju

doi:10.3988/jcn.2012.8.1.15

Cited by 247 publications

(277 citation statements)

References 70 publications

(86 reference statements)

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“…2 Tremor (4-7 Hz) in DIP usually affects the upper limbs, and present both at rest and activity, but, is less frequent than PD. 3 However, clinical manifestations alone cannot distinguish DIP from PD. 3 Imaging of striatal dopamine transporter using SinglePhoton Emission Computed Tomography (SPECT) using radioligand [ 123 I]FP-CIT (showing diminished nigro-striatal dopeminergic cell uptake in PD but not in DIP) may be helpful.…”

Section: Discussionmentioning

confidence: 99%

“…Amantadine is equally effective. 2,3 Usually, the symptoms resolve within weeks after discontinuation of offenders, but they respond remarkably to anticholinergics. 3 A long list of offending agents are available.…”

Section: Discussionmentioning

confidence: 99%

“…2,3 Usually, the symptoms resolve within weeks after discontinuation of offenders, but they respond remarkably to anticholinergics. 3 A long list of offending agents are available. 2,3 To the best of our knowledge, Pyrazinamide has not been reported as a cause of DIP yet in our country.…”

Section: Discussionmentioning

confidence: 99%

“…3 Imaging of striatal dopamine transporter using SinglePhoton Emission Computed Tomography (SPECT) using radioligand [ 123 I]FP-CIT (showing diminished nigro-striatal dopeminergic cell uptake in PD but not in DIP) may be helpful. 3,4 But we couldn't do that due to financial constraints. Once DIP has developed, offending drug should be identified and withdrawn.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4] Differentiating DIP from Parkinson's Disease (PD) may be difficult in many situations, but certain features help to establish the correct diagnosis. 2 DIP is generally characterized by acute/sub-acute onset, symmetric bilateral (sometimes unilateral) involvement, female predominance, more prominent bradykinesia and rigidity, and typical oro-masticatory dyskinesia (Rabbit syndrome -Strongly associated with DIP).…”

Section: Discussionmentioning

confidence: 99%

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Pyrazinamide Induced Parkinsonism

et al. 2017

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Parkinsonism refers to a syndrome characterized by the presence of tremor, rigidity and bradykinesia. In addition there is loss of postural reflexes as well as freezing. Drugs rank the second in the causes of parkinsonism. As it is reversible, drug-induced parkinsonism (Rabbit syndrome) should be borne in mind and suspected in any patient receiving drug treatment. We report a case of drug induced parkinsonism, evidently due to pyrazinamide. To the best of our knowledge, this is the first case to be reported in our country.J MEDICINE January 2017; 18 (1) : 42-43

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pyrazinamide Induced Parkinsonism

et al. 2017

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Risk of Developing Parkinson Disease in Bipolar Disorder

et al. 2020

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ipolar disorder (BD) is a mood disorder that has an early onset at a median age of 20 years. It is a long-term and recurrent disorder characterized by cyclic episodes of depression and either mania (BD type 1) or hypomania (BD type 2). Although the etiology of BD has not been established, it is a multifactorial disorder with genetic and environmental factors playing an important role. 1 Despite the pathophysiology of BD being uncertain, there is a putative role of the dopaminergic system, as levodopa has been shown to induce hypomania or mania in patients with BD, 2 and antipsychotic medications that block dopamine receptors can improve manic symptoms. 3 There is also evidence that the switch from a depressive to a manic state occurs concurrently with an upregulation of dopamine receptors. 4 The standard treatment for BD that includes lithium, antipsychotic medications, and antiepileptic medications may be associated with drug-induced parkinsonism, which is not clinically distinguishable from Parkinson disease (PD), both being characterized by bradykinesia, resting tremor, rigidity, and postural instability. [5][6][7] Since drug-induced parkinsonism is more common among patients with BD, physicians may be more inclined to misdiagnose PD as drug-induced parkinsonism. On the other hand, PD is typically seen in older patients. Small studies have previously shown that BD may be more common in patients with PD compared with the general population. 6 Therefore, we conducted a systematic review to assess the possible association of BD with a later diagnosis of idiopathic PD. IMPORTANCE Parkinson disease (PD) manifests by motor and nonmotor symptoms, which may be preceded by mood disorders by more than a decade. Bipolar disorder (BD) is characterized by cyclic episodes of depression and mania. It is also suggested that dopamine might be relevant in the pathophysiology of BD.OBJECTIVE To assess the association of BD with a later diagnosis of idiopathic PD.DATA SOURCES An electronic literature search was performed of Cochrane Controlled Register of Trials, MEDLINE, Embase, and PsycINFO from database inception to May 2019 using the terms Parkinson disease, bipolar disorder, and mania, with no constraints applied.STUDY SELECTION Studies that reported data on the likelihood of developing PD in BD vs non-BD populations were included. Two review authors independently conducted the study selection. DATA EXTRACTION AND SYNTHESISTwo review authors independently extracted study data. Data were pooled using a random-effects model, results were abstracted as odds ratios and 95% CIs, and heterogeneity was reported as I 2 . MAIN OUTCOME AND MEASURES Odds ratios of PD.RESULTS Seven studies were eligible for inclusion and included 4 374 211 participants overall. A previous diagnosis of BD increased the likelihood of a subsequent diagnosis of idiopathic PD (odds ratio, 3.35; 95% CI, 2.00-5.60; I 2 = 92%). A sensitivity analysis was performed by removing the studies that had a high risk of bias and also showed an increased risk of PD in pe...

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Amyotrophic lateral sclerosis—A case report and mechanistic review of the association with toluene and other volatile organic compounds

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Jabre

Ewing

et al. 2017

American J Industrial Med

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Unmasking of latent neurodegenerative disease has been reported following exposure to chemicals that share one or more mechanisms of action in common with those implicated in the specific disease. For example, unmasking of latent Parkinson's disease (PD) has been associated with exposure to anti-dopaminergic agents, while the progression of pre-existing mild cognitive impairment and unmasking of latent Alzheimer's disease has been associated with exposure to general anesthetic agents which promote Aβ protein aggregation. This literature review and clinical case report about a 45-year-old man with no family history of motor neuron disease who developed overt symptoms of a neuromuscular disorder in close temporal association with his unwitting occupational exposure to volatile organic compounds (VOCs) puts forth the hypothesis that exposure to VOCs such as toluene, which disrupt motor function and increase oxidative stress, can unmask latent ALS type neuromuscular disorder in susceptible individuals.

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Drug-Induced Parkinsonism

Cited by 247 publications

References 70 publications

Pyrazinamide Induced Parkinsonism

Pyrazinamide Induced Parkinsonism

Risk of Developing Parkinson Disease in Bipolar Disorder

Amyotrophic lateral sclerosis—A case report and mechanistic review of the association with toluene and other volatile organic compounds

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