Drug-Induced Pancreatitis

Trivedi, Chirag D.; Pitchumoni, C. S.

doi:10.1097/01.mcg.0000173929.60115.b4

Cited by 336 publications

(244 citation statements)

References 100 publications

(6 reference statements)

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“…Although prolonged remission may occur in early type 1 diabetes, this honeymoon period is unlikely to last 3 years. Atypical type 2 diabetes, characterized by ketosis at onset and subsequent remission, has been described in African patients but not in whites (1). Nonetheless, the negative antibodies and subsequent insulin independence in this case favor type 2 diabetes as the more likely diagnosis.…”

mentioning

confidence: 69%

Association of hGrb10 Genetic Variations With Type 2 Diabetes in Caucasian Subjects

et al. 2006

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confidence: 69%

Association of hGrb10 Genetic Variations With Type 2 Diabetes in Caucasian Subjects

et al. 2006

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“…In two large reviews, however, vincristine and vinblastine have been classified in the last class as the lowest list group in terms of triggering acute pancreatitis alone (5,8). In the literature, acute pancreatitis related to vinblastine has been reported in two cases with germ cell tumors (4).…”

Section: Discussionmentioning

confidence: 99%

“…In another classification based on number of published case reports, it is in the lowest risk group (5,8). Although acute pancreatitis has been reported with protocols combining its liposomal form with other agents, in general doxorubicin alone has never been blamed.…”

Section: Discussionmentioning

confidence: 99%

Acute Pancreatitis Following VAD Chemotherapy Combination Consisting Of Vincristine, Doxorubicin, And Dexamethasone In A Newly Diagnosed Multiple Myeloma Patient: A Case Report.

2012

IJO

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Background/Aims: The frequency of drug-related gastrointestinal adverse effects, including pancreatitis, has increased with the development and use of chemotherapeutic agents. Methods: In our country, a combination of vincristine, doxorubicin, and dexamethasone is frequently used as the first line of therapy in newly diagnosed multiple myeloma. A case with acute pancreatitis that we believe to depend on this therapy is presented. Results: In this case, after treatment of the acute pancreatitis episode in a very dynamic process, a proteasome inhibitor and following high dose chemotherapy with melphalan were used for the primary disease. Currently the patient is under follow-up at remission. Conclusion: It is important to consider chemotherapeutic agents as a possible etiology for acute pancreatitis in patients presenting with gastrointestinal symptoms, even after a few exposures to the agent.

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“…The incidence of acute pancreatitis may reach up to 40% of HIV seropositive individuals a year, which is considerably higher than for the general population, that has an incidence of 2%. 35 Pancreatitis has been predominantly associated with the usage of nucleoside reverse transcriptase inhibitors (NRTIs) such as didanosine and stavudine. 36 Being used widely and frequently, NSAIDs are often associated with ADEs.…”

Section: Discussionmentioning

confidence: 99%

Profile of serious adverse drug events in a tertiary care hospital of South India - a five years experience

Jayanthi

Pasha

Sushma

2017

Int J Basic Clin Pharmacol

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Background: Adverse drug event (ADE) is said to be serious, when it is life-threatening, leads to hospitalization, disability, congenital anomaly, death or requires intervention to prevent permanent impairment or damage. The present study aimed to determine the pattern, causality, preventability of serious ADEs.Methods: This retrospective study was carried out to profile serious ADEs reported from Bangalore Medical College and Research Institute to Adverse Drug Reaction (ADR) Monitoring Centre, under Pharmacovigilance Programme of India from 2012 to 2016. Patient demographics, clinical and drug data, details of the ADE, onset time, causal drug details, outcome and severity were collected as per CDSCO form. Causality was assessed by WHO-ADR probability scale, preventability by modified Schumock and Thornton scale.Results: A total of 809 ADEs were reported, of which 50 (6.18%) were serious in nature. Male preponderance (74%) was observed, with 42% among patients aged 20-40 years. 56% of serious ADEs were reported from department of Dermatology. Steven Johnson Syndrome (SJS) (20%) contributed for most of the ADEs. Antiepileptics caused maximum number of serious ADEs (32%). 76% of the ADEs were found to be ‘probable’ and 4% were definitely preventable. 56% of them was life threatening and 86% required intensive interventions. 16% patients experienced serious ADEs during hospital stay.Conclusions: Serious ADEs constituted 6.18% of all ADEs reported. SJS was commonly seen with antimicrobials and hepatotoxicity with ATT. Antiepileptics and ATT contributed for majority of them. This study highlights the importance of monitoring and timely management of serious ADEs to commonly prescribed medications.

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Drug-Induced Pancreatitis

Cited by 336 publications

References 100 publications

Association of hGrb10 Genetic Variations With Type 2 Diabetes in Caucasian Subjects

Association of hGrb10 Genetic Variations With Type 2 Diabetes in Caucasian Subjects

Acute Pancreatitis Following VAD Chemotherapy Combination Consisting Of Vincristine, Doxorubicin, And Dexamethasone In A Newly Diagnosed Multiple Myeloma Patient: A Case Report.

Profile of serious adverse drug events in a tertiary care hospital of South India - a five years experience

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