Drug-Induced p53 Activation Promotes Acinar Cell Identity and Prevents Pancreatic Cancer Initiation
Jennifer J Twardowski,
Thomas I Heist,
Zamira Guerra Soares
et al.
Abstract:Pancreatitis is a painful inflammatory disease that carries an increased risk of developing pancreatic cancer. Patients with this disease experience acinar-to-ductal metaplasia (ADM), a process in which their pancreatic acinar cells dedifferentiate into a more ductal-like state. Metaplastic cells can proliferate and repopulate the pancreas before redifferentiating into functional acini. However, when metaplastic cells develop activating mutations in the oncogene Kras, they can progress into pancreatic intraepi… Show more
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