Drug-Induced Nephrotoxicity

Reis, Adriano Max Moreira

doi:10.1007/978-3-030-37655-0_6

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2022

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(2 citation statements)

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“…According to statistics, drug‐induced renal failure accounts for 25% of all acute renal failure cases, and the incidence rate in elderly patients is even as high as 60% (Hernandez et al, 2011). Patients will be more exposed to a variety of potential nephrotoxic drugs, including prescription drugs, over‐the‐counter drugs, diagnostic agents, and herbal medicines (Reis, 2020). Drugs used to treat a variety of diseases are also potentially nephrotoxic, including some antibiotics, analgesics, anticancer drugs, and immunosuppressants (Awdishu, 2017; Kane‐Gill & Goldstein, 2015).…”

Section: Introductionmentioning

confidence: 99%

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In silico prediction of potential drug‐induced nephrotoxicity with machine learning methods

Gong

Teng

Wang

et al. 2022

J of Applied Toxicology

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In recent years, drug-induced nephrotoxicity has been one of the main reasons for the failure of drug development. Early prediction of the nephrotoxicity for drug candidates is critical to the success of clinical trials. Therefore, it is very important to construct an effective model that can predict the potential nephrotoxicity of compounds. Machine learning methods have been widely used to predict the physico-

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Section: Introductionmentioning

confidence: 99%

“…Kidney disease or impairment of function caused by drugs is called drug-induced nephrotoxicity (DIN) (Reis, 2020). Because different drugs have different mechanisms and degrees of damage to different segments of the nephron, the judgment index of nephrotoxicity is not unique, that is, it has a broad spectrum.…”

Section: Introductionmentioning

confidence: 99%