Drug-induced lymphocyte stimulation test in the prediction of drug-induced hypersensitivity to antituberculosis drugs

Sensitivity and specificity of the lymphocyte transformation test in drug reaction with eosinophilia and systemic symptoms causality assessment

“…LTT with antituberculosis drugs showed an 87.5% sensitivity and 100% specificity. Similar specificity values and much lower sensitivity values were previously reported . However, both groups performed LTT studies in the acute phase, which could explain the low sensitivity, and included various clinical entities.…”

“…Similar specificity values and much lower sensitivity values were previously reported. 41,42 However, both groups performed LTT studies in the acute phase, which could explain the low sensitivity, and included various clinical entities. Our results in the recovery phase suggest a diagnostic role for LTT in antituberculosis drug-induced DRESS.…”

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by first‐line antituberculosis drugs: Two case reports and a review of the literature

“…For example, Ye et al showed specific T cell responses to isoniazid and rifampicin in patients with antituberculosis drug‐induced DRESS syndrome or maculopapular exanthema. However, the apparent limited sensitivity of the LTT prevents it from replacing drug provocation tests at present, although its good specificity might aid in incriminating a particular drug . Besides questions regarding its sensitivity, the LTT is also a time‐consuming test and is not readily available, especially in those countries where tuberculosis is currently very prevalent.…”

“…However, the apparent limited sensitivity of the LTT prevents it from replacing drug provocation tests at present, although its good specificity might aid in incriminating a particular drug. 30 Besides questions regarding its sensitivity, the LTT is also a time-consuming test and is not readily available, especially in those countries where tuberculosis is currently very prevalent. Reintroduction, of course, requires the patient to be effectively suffering from tuberculosis, with microorganisms sensitive to the antibiotics that will be reintroduced, without any existing therapeutic alternatives, and rechallenges should, in any case, be performed in a hospital setting.…”

Fever as a predictor of positive lymphocyte transformation test

“…[9][10][11] The lymphocyte transformation test (LTT) is an in vitro laboratory-based method, which offers safety and reproducibility in diagnosing type IV hypersensitivity. 6,12,13 The aim of this study was therefore to evaluate the clinical characteristics of AH confirmed on LTT in children. We also sought to compare the clinical characteristics between LTTpositive and LTT-negative cases to identify features suggestive of AH.…”