Drug-induced liver injury in liver biopsies of the years 1981 and 1983, their prevalence and type of presentation

Koch, H; A, Gropp; Oehlert, W

doi:10.1016/s0344-0338(85)80186-2

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Cited by 9 publications

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“…

P henprocoumon ist eine potentiell hepatotoxische Substanz [1][2][3][4][5][6][7][8][9][10][11]. Im Allgemeinen sind nach Absetzen des Cumarins die hepatischen Veränderun-gen reversibel [2].

…”

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Off-Label-Use in der Langzeitantikoagulation nach Lebertransplantation wegen phenprocoumoninduzierten Leberversagens

et al. 2005

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A low-molecular-weight heparin appears to be the most appropriate way to maintain effective and safe anticoagulation in this patient. Coumarins carry a residual risk of an extrahepatic, immunologically mediated cross-sensitization. Long-term use of ximelagatran may also cause liver damage. For heparinoids, hirudins, and other drugs affecting coagulation like platelet aggregation inhibitors, therapeutic evidence is not sufficient. Though subcutaneous application of heparin is a disadvantage for the patient, therapeutic alternatives do not have better documented efficacy or less hepatotoxic potential. The low-molecular-weight heparin fulfills the criteria for refunding set by federal jurisdiction.

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“…

P henprocoumon ist eine potentiell hepatotoxische Substanz [1][2][3][4][5][6][7][8][9][10][11]. Im Allgemeinen sind nach Absetzen des Cumarins die hepatischen Veränderun-gen reversibel [2].

…”

unclassified