Drug‐induced liver injury at an Asian center: a prospective study

Wai, Chun-Tao; Tan, Bee-Him; Chan, Cheng-Leng; Sutedja, Dede Selamat; Lee, Yin-Mei; Khor, Christopher Jen Lock; Lim, Seng-Gee

doi:10.1111/j.1478-3231.2007.01461.x

Cited by 143 publications

(109 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Finally, CAM including herbal medicines is increasingly becoming popular with an attendant increase in cases of hepatotoxicity ( 9,13 ). Despite stringent history taking, we encountered only a small number of patients with ayurvedic medicines (CAM) that induced DILI.…”

Section: Livermentioning

confidence: 99%

Single-Center Experience With Drug-Induced Liver Injury From India: Causes, Outcome, Prognosis, and Predictors of Mortality

Devarbhavi

Dierkhising

Kremers

et al. 2010

American Journal of Gastroenterology

205

190

View full text Add to dashboard Cite

Although drug-induced liver injury (DILI) is rare, it may result in signifi cant morbidity or death. The causes and outcome vary according to regions, with acetaminophen and complementary medicines common in the West and the Far East, respectively. This study evaluates the causes, outcomes, predictors, and models for 90-day mortality from DILI from India. METHODS:Consecutive patients with DILI from 1997 to 2008 based on International Consensus Criteria from a medical college hospital setting were studied. RESULTS:Of the 313 patients, 58 % were males. Leading causes were a combination of four anti-tuberculous drugs (ATDs) (58 % ), anti-epileptics ( SUPPLEMENTARY MATERIAL is linked to the online version of the paper at

show abstract

Section: Livermentioning

confidence: 99%

Single-Center Experience With Drug-Induced Liver Injury From India: Causes, Outcome, Prognosis, and Predictors of Mortality

Devarbhavi

Dierkhising

Kremers

et al. 2010

American Journal of Gastroenterology

205

190

View full text Add to dashboard Cite

show abstract

“…However, there are increased reports about the hepatotoxicity induced by herbal medicines. For example, herbal medicines as dietary supplements caused about 9% of cases of DILI, while in Asia the percentage was about 20-55% cases of DILI (8,9). Thus, liver injury induced by herbal medicines needs to be paid more attention.…”

Section: Introductionmentioning

confidence: 99%

Cytokines as potential biomarkers of liver toxicity induced by Dioscorea bulbifera L.

Sheng

Deng

et al. 2014

BST

View full text Add to dashboard Cite

“…[1][2][3][4][5] Aside from the multicenter study by Squires et al 6 on acute liver failure (ALF), which included drug-induced ALF (DIALF) caused by paracetamol (n ¼ 48) and nonparacetamol drugs (n ¼ 14), there are no systematic studies available on DILI in children. 7 Case reports describing the spectrum, ranging from acute hepatitis to chronicity, have been published.…”

mentioning

confidence: 99%

Drug-Induced liver injury with hypersensitivity features has a better outcome: A single-center experience of 39 children and adolescents

Devarbhavi

Karanth

et al. 2011

Hepatology

View full text Add to dashboard Cite

Drug-induced liver injury (DILI) is rare in children and adolescents, and, consequently, data are remarkably limited. We analyzed the causes, clinical and biochemical features, natural history, and outcomes of children with DILI. Consecutive children with DILI from 1997 to 2004 (retrospective) and 2005 to 2010 (prospective) were studied based on standard criteria for DILI. Thirty-nine children constituted 8.7% of 450 cases of DILI. There were 22 boys and 17 girls. Median age was 16 years (range, 2.6-17). Combination antituberculous drugs were the most common cause (n 5 22), followed by the anticonvulsants, phenytoin (n 5 10) and carbamazepine (n 5 6). All of the 16 children (41%) who developed hypersensitivity features, such as skin rashes, fever, lymphadenopathy, and/or eosinophilia, including the 3 with Stevens-Johnson syndrome, survived. Those with hypersensitivity presented earlier (24.5 versus 35 days; P 5 0.24) had less severe disease (MELD, 16 versus 29; P 5 0.01) and had no mortality (0/16 versus 12/23; P < 0.001), compared to those without hypersensitivity. The 12 fatalities were largely the result of antituberculous DILI (n 5 11). The presence of encephalopathy and ascites were associated with mortality, along with hyperbilirubinemia, high international normalized ratio, and serum creatinine. According to the Roussel Uclaf Causality Assessment Method, 18 were highly probable, 14 probable, and 7 possible. Thirty-two children were hospitalized. Conclusion: DILI is not uncommon in children and accounts for 8.7% of all patients with DILI. Antituberculous drugs and anticonvulsants are the leading causes of DILI in India. Overall mortality is high (30.7%), largely accounted by antituberculous drugs. Children with DILI and hypersensitivity features present early, have less severe disease, and, consequently, a better prognosis, compared to those without, and are often associated with anticonvulsants or sulfonamides. (HEPATOLOGY 2011;54:1344-1350 T he last decade has seen an increasing number of reports on drug-induced liver injury (DILI) in adults across all regions of the world.

show abstract

Drug‐induced liver injury at an Asian center: a prospective study

Abstract: DILI in Asia has a different aetiology as compared with the West, and could be related to presence of adulterants in traditional CAM.

Cited by 143 publications

References 25 publications

Single-Center Experience With Drug-Induced Liver Injury From India: Causes, Outcome, Prognosis, and Predictors of Mortality

Single-Center Experience With Drug-Induced Liver Injury From India: Causes, Outcome, Prognosis, and Predictors of Mortality

Cytokines as potential biomarkers of liver toxicity induced by Dioscorea bulbifera L.

Drug-Induced liver injury with hypersensitivity features has a better outcome: A single-center experience of 39 children and adolescents

Contact Info

Product

Resources

About