Drug Induced Liver Disease

Petrovic-Subic, Narcisa; Kojič, Miroslav

doi:10.22190/fumb170330008p

Cited by 1 publication

(1 citation statement)

References 27 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cis‐diamminedichloroplatinum(II) also known as cisplatin is a well‐known chemotherapeutic drug used for treatment of numerous human cancers including lung, ovarian, bladder, head, testicular and neck cancers. It acts by crosslinking with the purine bases in the DNA, inducing DNA damage, interfering with DNA repair mechanisms and subsequently inducing apoptosis in cancer cells (Dasari & Bernard Tchounwou, 2014; Petrović & Todorović, 2016) (Figure 4). Cisplatin is an important clinical chemotherapeutic drug routinely used for the treatment lung adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Shielding and nurturing: Fibronectin as a modulator of cancer drug resistance

Farooq

Amin

Wani

et al. 2023

Journal Cellular Physiology

View full text Add to dashboard Cite

Resistance to chemotherapy and targeted therapies constitute a common hallmark of most cancers and represent a dominant factor fostering tumor relapse and metastasis. Fibronectin, an abundant extracellular matrix glycoprotein, has long been proposed to play an important role in the pathobiology of cancer. Recent research has unraveled the role of Fibronectin in the onset of chemoresistance against a variety of antineoplastic drugs including DNA‐damaging agents, hormone receptor antagonists, tyrosine kinase inhibitors, microtubule destabilizing agents, etc. The current review summarizes the role played by Fibronectin in mediating drug resistance against diverse anticancer drugs. We have also discussed how the aberrant expression of Fibronectin drives the oncogenic signaling pathways ultimately leading to drug resistance through the inhibition of apoptosis, promotion of cancer cell growth and proliferation.

show abstract

Section: Introductionmentioning

confidence: 99%