Drug-Induced Intracranial Hypertension: A Systematic Review and Critical Assessment of Drug-Induced Causes

Tan, Marcus G.; Worley, Brandon; Kim, Whan B.; Hove, Martin ten; Beecker, Jennifer

doi:10.1007/s40257-019-00485-z

Cited by 52 publications

(46 citation statements)

References 31 publications

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“…A recent systematic review proposed a set of diagnostic criteria for DIIH, elucidating that vitamin A derivatives and tetracycline-class antibiotics are among the highest-risk category. 1 They are both category V medications (medications found to be most strongly associated with DIIH) 1 and may even have a synergistic effect on inducing DIIH. 6 Studies have demonstrated that tetracyclines should not be prescribed concurrently with isotretinoin, and a drug-free period of at least seven days is recommended to achieve theoretical drug clearance.…”

Section: Discussionmentioning

confidence: 99%

“…Presenting symptoms including headaches, transient visual obscurations, and compressive optic neuropathy leading to irreversible severe visual impairment are well-documented. 1 There remains a paucity of data regarding topical tretinoin and its association with secondary intracranial hypertension. Thought to be a safer option than systemic isotretinoin, topical tretinoin, or all-trans-retinoic acid, is an active intracellular metabolite of isotretinoin (13- cis -retinoic acid) often prescribed as a first-line treatment for patients with mild-to-moderate acne vulgaris.…”

Section: Introductionmentioning

confidence: 99%

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Intracranial hypertension associated with topical tretinoin use

Gasparian

Geng

Hawy

2021

American Journal of Ophthalmology Case Reports

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Purpose To report cross-reactivity between topical vitamin A derivatives and tetracycline-class antibiotics. Observations A 19-year old woman with a remote history of resolved secondary intracranial hypertension due to minocycline use developed intracranial hypertension while using topical tretinoin alone. Examination demonstrated bilateral optic nerve edema, a right sixth cranial nerve palsy, along with characteristic features of markedly elevated intracranial pressure on imaging. Lumbar puncture opening pressure was 60 cmH 2 O. Cessation of topical tretinoin use ensued complete resolution of symptoms and optic nerve swelling in both eyes. Conclusions and importance Our findings substantiate the need to avoid topical vitamin A derivatives and alternate drug classes known to be associated with drug-induced intracranial hypertension.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intracranial hypertension associated with topical tretinoin use

Gasparian

Geng

Hawy

2021

American Journal of Ophthalmology Case Reports

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“…Additionally, there have been certain medications that have been linked to development of IIH including antibiotics in the class of tetracyclines, Vitamin-A derivatives, growth hormone, and lithium. 11 These risk factors, however, do not account for all patients and do not provide a complete picture behind the origin of IIH. Indeed, it appears that there is no single cause of IIH, but rather it can arise from a variety of mechanisms and risk factors, ultimately leading to the same result of increasing ICP.…”

Section: Etiologymentioning

confidence: 99%

“…Additionally, recombinant growth hormone and Lithium has also been associated with high risk of development of IIH. 11 Other drugs like corticosteroids, cyclosporin, oral contraceptives and fluoroquinolones have a lesser risk to develop IIH. 11…”

Section: Medicationsmentioning

confidence: 99%

Etiology, pathogenesis and management of idiopathic intracranial hypertension, and role of optic canal size in asymmetric papilledema: A review

Mitchell

Mathew

Harris

et al. 2021

European Journal of Ophthalmology

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Idiopathic intracranial hypertension (IIH) is characterized by raised intracranial pressure of unknown origin that primarily afflicts obese women of childbearing age. There are several treatment options, but currently there are none that are effective for the entire affected population. The lack of a universally effective treatment is related to an incomplete understanding of the etiology of the condition and the lack of a well-defined pathophysiological mechanism for the disease process. Classically, IIH has been thought of as a diagnosis of exclusion once radiographical imaging has ruled out all other causes of elevated intracranial pressure. Today, we know that imaging does capture subtle changes, and might provide keys to finally understand the pathogenesis of IIH so that a definitive treatment can be discovered or developed. Recently, advancements in radiography, optical coherence tomography, and electroretinography have shown promise for the future of IIH evaluation. A topic within IIH imaging that has recently sparked interest is the possibility that the severity of papilledema may have an association with the size of the optic canal. In this article, we also discuss the recent studies on the relationship between asymmetric papilledema and optic canal size.

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“…Íåùîäàâíî âèÿâëåíà àñîö³àö³ÿ ì³ae âèêîðèñòàííÿì ôòîðõ³íîëîí³â äðóãîãî-òðåòüîãî ïîêîë³ííÿ ³ç ³ä³îïàòè÷íîþ âíóòð³øíüî÷åðåïíîþ ã³ïåðòåíç³ºþ [36]. Íàéá³ëüø âèðàaeåíà àíòèá³îòèê-³íäóêîâàíà íåéðîòîêñè÷í³ñòü â³äì³÷åíà ó ïàö³ºíò³â ³ç õðîí³÷íîþ õâîðîáîþ íèðîê, ÿê³ ïðèéìàëè ëåâîôëîêñàöèí â êîìá³íàö³¿ ³ç ìåòðîí³äàçîëîì [37].…”

Section: òàáëèöÿ 2 ì³í³ìàëüíà ³íã³áóþ÷à êîíöåíòðàö³ÿ öèïðîôëîêñàöèíóunclassified

CLINICAL PHARMACOLOGY OF FLOROCHINOLONS: A FOCUS ON SAFETY. Review

Кhaitovych¹

2019

Med. Sci. of Ukr.

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Fluoroquinolones are effective in the treatment of infections of almost any localization (upper and lower respiratory tract, urinary system, skin and soft tissues, bones and joints, liver and bile ducts, gastrointestinal tract, female genital tract, central nervous system, intra-abdominal), sexually transmitted infections. Resistance is slowly formed to fluoroquinolones. Among the benefits of certain fluoroquinolones are that they can be administered either orally or intravenously. Fluoroquinolones can also be combined with antibacterial agents of other groups. Levofloxacin (the left-turning isomer of ofloxacin) has now become one of the most commonly used antibiotics. This is because the drug exhibits high tissue penetration, creating in the alveolar macrophages, the mucous membranes of the bronchi and fluid lining the respiratory epithelium, a concentration that is significantly higher than the MIC to respiratory pathogens. The literature review presents current insights on the pharmacokinetics, pharmacodynamics, and adverse effects of fluoroquinolones. The risks of tendinitis, tendon ruptures, aortic aneurysm / dissection, QT prolongation, recurrence of C.difficile antibiotic-associated diarrhea, hypo- and hyperglycemic conditions are emphasized. The clinical role of fluoroquinolones inhibitory effect on cytochrome P450 isoenzymes CYP1A2 and CYP2C9 activities, which metabolize many drugs with low therapeutic index (derivatives of sulfonylureas, warfarin, phenytoin, and theophylline etc). Therefore, when deciding on the prescription of fluoroquinolones, especially for elderly patients, the doctor should collect a detailed anamnesis, in particular regarding the administration of drugs with a small therapeutic index, and conduct therapeutic drug monitoring, including monitoring blood glucose levels.

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Drug-Induced Intracranial Hypertension: A Systematic Review and Critical Assessment of Drug-Induced Causes

Cited by 52 publications

References 31 publications

Intracranial hypertension associated with topical tretinoin use

Intracranial hypertension associated with topical tretinoin use

Etiology, pathogenesis and management of idiopathic intracranial hypertension, and role of optic canal size in asymmetric papilledema: A review

CLINICAL PHARMACOLOGY OF FLOROCHINOLONS: A FOCUS ON SAFETY. Review

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