Drug-induced impairment of renal function

Pazhayattil, George Sunny; Shirali, Anushree C.

doi:10.2147/ijnrd.s39747

Cited by 117 publications

(75 citation statements)

References 101 publications

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“…Volume depletion increases the risk by changing the drug concentration to a toxic level. Hypoalbuminemia, commonly observed in cirrhotic patients, increases the risk of unwanted drug overdose by elevating the serum concentration of the unbound drug fractions (Pazhayattil and Shirali 2014). Both elderly and neonates possess a particular risk for drug-induced nephrotoxicity.…”

Section: Patient-specific Risk Factorsmentioning

confidence: 99%

Kidney-based in vitro models for drug-induced toxicity testing

et al. 2019

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The kidney is frequently involved in adverse effects caused by exposure to foreign compounds, including drugs. An early prediction of those effects is crucial for allowing novel, safe drugs entering the market. Yet, in current pharmacotherapy, drug-induced nephrotoxicity accounts for up to 25% of the reported serious adverse effects, of which one-third is attributed to antimicrobials use. Adverse drug effects can be due to direct toxicity, for instance as a result of kidney-specific determinants, or indirectly by, e.g., vascular effects or crystals deposition. Currently used in vitro assays do not adequately predict in vivo observed effects, predominantly due to an inadequate preservation of the organs' microenvironment in the models applied. The kidney is highly complex, composed of a filter unit and a tubular segment, together containing over 20 different cell types. The tubular epithelium is highly polarized, and the maintenance of this polarity is critical for optimal functioning and response to environmental signals. Cell polarity is dependent on communication between cells, which includes paracrine and autocrine signals, as well as biomechanic and chemotactic processes. These processes all influence kidney cell proliferation, migration, and differentiation. For drug disposition studies, this microenvironment is essential for prediction of toxic responses. This review provides an overview of drug-induced injuries to the kidney, details on relevant and translational biomarkers, and advances in 3D cultures of human renal cells, including organoids and kidney-on-a-chip platforms.

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Section: Patient-specific Risk Factorsmentioning

confidence: 99%

Kidney-based in vitro models for drug-induced toxicity testing

et al. 2019

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“…7% of people develop nephrotic syndrome with kidney biopsy demonstrating membranous nephropathy (Singh et al, 2003). Acute kidney injury is caused due to polymyxins (polymyxin B and colistin) by toxic, toxic tubular injury (Justo and Bosso, 2015;Shirali and Pazhayattil, 2014).…”

Section: Penicillaminementioning

confidence: 99%

“…Nephrotoxicity disorder is commonly found in many chemotherapeutical agents; these lead to comprehensive renal complications (Shirali and Pazhayattil, 2014).…”

Section: Chemotherapeutic Agentsmentioning

confidence: 99%

Drug-induced renal disorder-A Mini Review

Divya¹,

Nivetha²,

Mohan³

et al. 2020

ijrps

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Drug-induced kidney disorder/disease (DKID) is an origin of kidney disease followed by acute renal failure. Drug-induced renal toxicity is more common in infants and young children in certain clinical circumstances where underlying renal dysfunction and cardiovascular diseases. Sometimes, administered drugs may cause acute renal injury, intra-renal obstruction, interstitial nephritis, nephrotic syndrome, and acid-base and fluid electrolytes disorders in patients. Certain drugs may cause alterations in intra-glomerular hemodynamics, inflammatory changes in renal tubular cells, leading to acute kidney injury (AKI), interstitial tubule disease, and renal scarring. Common risk factors include; pre-existing renal dysfunction, volume-depleted state, old age, and use of nephrotoxic drugs. Therefore, the prevention from the disease includes the knowledge about the nephrotoxicity, assessing considering the patient-related, kidney-related, and drug-related factors while prescribing medicines, using of alternative drugs, which are non-nephrotoxic, assessing the baseline of renal function before starting the treatment, monitor the renal function during the treatment and avoid the nephrotoxic drug combinations and withdrawing the offending drugs due to toxicity. The ADRs of the prescribed/ administered are identified at the earliest to prevent the development of the last-stage renal disorder. This review discusses the risk factors associated with drug-induced renal disease, estimation of renal function, mechanism of drug-induced nephrotoxicity, and certain drugs that cause nephrotoxicity.

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“…• Выполнить общий анализ мочи (ОАМ), определить уровень креатинина в сыворотке крови, рассчитать скорость клубочковой фильтрации (СКФ) по формуле CKD-EPI [43,44].…”

Section: перед началом леченияunclassified

Use of Nonsteroidal Anti-Inflammatory Drugs and Biological Agents for the Treatment of Axial Spondyloarthritides. Recommendations of the Spondyloarthritis Study Group of Experts, All-Russian Public Organization «the Association of Rheumatology of Russia»

Гайдукова¹,

Ребров²,

Лапшина³

et al. 2017

rsp

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В статье представлены рекомендации по лекарственной терапии аксиальных спондилоартритов, разработан-ные Экспертной группой по изучению спондилоартритов (ЭкСпА). Рекомендации описывают тактику веде-ния пациентов в наиболее частых клинических ситуациях, направленную на обеспечение максимальной эф-фективности и безопасности лечения. Ключевые слова: спондилоартриты; аксиальные спондилоартриты; анкилозирующий спондилит; болезнь Бехтерева; нестероидные противовоспалительные препараты; ингибиторы фактора некроза опухоли α; ин-гибиторы интерлейкина 17; безопасность терапии. Для ссылки: Гайдукова ИЗ, Ребров АП, Лапшина СА и др. Применение нестероидных противовоспали-тельных препаратов и генно-инженерных биологических препаратов для лечения аксиальных спондилоар-тритов. Рекомендации Экспертной группы по изучению спондилоартритов при Общероссийской общест-венной организации «Ассоциация ревматологов России». Научно-практическая ревматология. 2017;55(5):474-484. The paper gives recommendations for the drug therapy of axial spondyloarthritides, which have been developed by the Spondyloarthritis Study Group of Experts. The recommendations describe the patient management tactic in the most common clinical situations, which is aimed at maximizing the efficacy and safety of treatment. Key words: spondyloarthritides; axial spondyloarthritides; ankylosing spondylitis; Bechterew's disease; nonsteroidal anti-inflammatory drugs; tumor necrosis factor-α inhibitors; interleukin-17 inhibitors; safety of therapy. For reference: Gaidukova IZ, Rebrov AP, Lapshina SA, et al. Use of nonsteroidal anti-inflammatory drugs and biological agents for the treatment of axial spondyloarthritides. USE OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS AND BIOLOGICAL AGENTS FOR THE TREATMENT OF AXIAL SPONDYLOARTHRITIDES. RECOMMENDATIONS OF THE SPONDYLOARTHRITIS STUDY GROUP OF EXPERTS, ALL-RUSSIAN PUBLIC ORGANIZATION «THE ASSOCIATION OF RHEUMATOLOGY

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Drug-induced impairment of renal function

Cited by 117 publications

References 101 publications

Kidney-based in vitro models for drug-induced toxicity testing

Kidney-based in vitro models for drug-induced toxicity testing

Drug-induced renal disorder-A Mini Review

Use of Nonsteroidal Anti-Inflammatory Drugs and Biological Agents for the Treatment of Axial Spondyloarthritides. Recommendations of the Spondyloarthritis Study Group of Experts, All-Russian Public Organization «the Association of Rheumatology of Russia»

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