Drug induced impairment of polymorphonuclear cell bactericidal ability in rheumatoid arthritis.

Abstract

SUMMARY Thirty three patients with rheumatoid arthritis (RA) treated only with non-steroidal anti-inflammatory drugs were divided into two groups according to the drug received (group A: diclofenac, group B: indomethacin or ketoprofen), and their polymorphonuclear (PMN) cell functions were investigated. We found that bactericidal ability was the only function significantly impaired in group A as compared with group B patients and normal controls. This modification correlated well with the reduction of control PMN bactericidal ability when this test was carried out in patient plasma. These differences between drug effects might explain some of the discrepancies between reports of PMN cell functions in RA.

Cell-Free Fc-Gamma Receptor III in Sera from Patients with Systemic Lupus Erythematosus: Correlation with Clinical and Biological Features

“…Evaluation of PMN cell functions has pro ven relevant to the understanding of the physiopathology in non-organ-specific autoimmune diseases [19]. Many studies on the functional state of PMN cells have been car-ricd out with rheumatoid arthritis patients and a multiple defect has been described [19][20][21], As for SLE patients, a consensus concerning the functional state of PMN cells has not yet been reached. Since PMN cells expressing FcyR are thought to be functionally more efficient, it is reasonable to assume that the interpretation of impaired functioning of PMN cells needs to take into account cellfree FcyRIII.…”

Effects of temperature on chemiluminescence of phagocytes from sea bass, Dicentrarchus labrax L.

“…Phagocytosis is undoubtedly a very important first line defence mechanism of fish (Avtalion & Shahrabani 1975;Braun-Nesje, Bertheussen, Kaplan & Seljelid 1981;Honda, Kodama, Moustafa, Yamada, Mikami & Izawa 1985). Several methods using latex particles (Youinou & Le Goff 1987), carbon (Ellis, Munroe & Roberts 1976;Ferguson 1975), bacteria (Bell 1976;Suzuki 1984) or sheep red blood cells (Braun-Nesje, Kaplan & Seljelid 1982) have been reported in order to measure phagocytosis. Since the report of Allen, Stjernholm & Steele (1972) chemiluminescence has been used to evaluate phagocyte activity.…”