Drug-Induced Hepatic Microgranulomatosis in Cynomolgus Monkeys

Abstract

This report discusses a unique drug-induced hepatotoxicity in cynomolgus monkeys treated orally with a novel potassium sparing experimental diuretic, [2,6-bis(4-chlorophenyl

Hepatic Effects in Beagle Dogs Administered Atorvastatin, a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, for 2 Years

“…In humans, granulomatous response in liver has been associated with several drugs (14). Microgranulomas were described in monkeys treated with an experimental diuretic (16), in dogs treated with a protease inhibitor (17), and in rats given a sterol compound (13). The microgranulomas in livers of dogs in this study consisted mainly of mononuclear phagocytes, many of which were pigmented, a result of incomplete degradation of senescent, lipofuscin-filled hepatocytes.…”

“…In humans, granulomatous response in liver has been associated with several drugs (14). Microgranulomas were described in monkeys treated with an experimental diuretic (16), in dogs treated with a protease inhibitor (17), and in rats given a sterol compound (13). The (27) and was present at all sacrifice time points in this study, but severity was less at 104 wk than at 52 wk.…”