1987
DOI: 10.14219/jada.archive.1987.0050
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Drug-induced gingival hyperplasia: phenytoin, cyclosporine, and nifedipine

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Cited by 113 publications
(54 citation statements)
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“…Periodontal tissue damage is not seen in most of the cases. 42 The incidence and severity of gingival enlargement due to phenytoin usage is maximum in labial surfaces of mandibular and maxillary anterior teeth. 36 ( Figure-2) Three months after initiation of the treatment, the enlargement begins to occur and makes its peak in the first year.…”
Section: Clinical Manifestationsmentioning
confidence: 99%
“…Periodontal tissue damage is not seen in most of the cases. 42 The incidence and severity of gingival enlargement due to phenytoin usage is maximum in labial surfaces of mandibular and maxillary anterior teeth. 36 ( Figure-2) Three months after initiation of the treatment, the enlargement begins to occur and makes its peak in the first year.…”
Section: Clinical Manifestationsmentioning
confidence: 99%
“…1 These aberrations can adversely affect speech, mastication, tooth eruption, and esthetics. 2 Several factors namely; age, genetic predisposition, presence of preexisting plaque, and gingival inflammation influence the relationship between the drugs and gingival tissue. 3 Calcium channel blockers are regularly prescribed in the treatment of conditions such as hypertension and angina.…”
Section: Introduction:-mentioning
confidence: 99%
“…Bugüne kadar yapılan araştırmalarda CsA kullanılan hastalarda dişeti büyümesi görülme sıklığı %25-30 olduğu bildirilmiştir. [7][8][9] Ġlaca bağlı dişeti büyümelerinin mekanizması kesin olarak anlaşılamamıştır; fakat dişeti büyümeleri multifaktöriyel etkenlere bağlanmıştır. Birçok çalışma göstermiştir ki, dişeti büyümesine eğilimli olan bireylerde fenitoin, siklosporin ve kalsiyum-kanal blokerleriyle epitel dokusundaki keratositler, fibroblastlar ve kollajenlerle etkileşimleri dişeti büyümesine neden olabilir.…”
Section: Introductionunclassified