Drug-Induced Gastrointestinal Tract Injury

Mannan, Rifat; Waters, Kevin M.; Montgomery, Elizabeth A.

doi:10.1007/978-3-030-51268-2_11

Cited by 2 publications

(2 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to reports, elderly individuals are more likely to suffer from pill-induced esophageal damage than younger ones, as they consume more medications including NSAIDs or bisphosphonates due to multiple co-morbidities, have more disorders of esophageal motility or compression of middle esophagus due to cardiac enlargement, and are less aware about the instructions of medication use. 13 The esophageal transit time was shown to be significantly longer in elderly individuals than in younger subjects in a study. 14 But pill-induced esophageal injury can be seen in different age groups with different medications.…”

Section: Discussionmentioning

confidence: 92%

Clinical and endoscopic features of pill-induced esophagitis

Patel

Panchal

Patel³

et al. 2022

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Background: Medication can cause an injury in the esophagus by local and systemic effect, leading to esophagitis. Many such medications have been identified as a cause of pill-induced esophagitis. This study was performed to evaluate the clinical and endoscopic findings of pill-induced esophagitis.Methods: This was retrospective observational study, conducted among patients diagnosed endoscopically with pill-induced esophagitis at Ansh gastroenterology clinic, Ahmedabad, India, from April 2017 to March 2021. The data of these patients were recorded in pre-designed case record form by evaluating their past medical records.Results: Total 90 patients were diagnosed with pill-induced esophagitis. Retrosternal chest pain (68.9%), odynophagia (41.1%), dysphagia (25.6%), and epigastric pain (14.4%) were common clinical findings. The major culprit medications were antibiotics, and NSAIDs (non-steroidal anti-inflammatory drugs). Common esophageal endoscopic findings were ulcer (84.4%), erosion (17.8%), and active ulcer bleeding (12.2%). Kissing ulcers were observed in the majority (46.7%) of cases. The majority of ulcer and erosion were located in middle third of the esophagus. All the patients were recovered within 6 to 10 days after treatment with PPIs (proton pump inhibitors) and/or antacids, and withdrawal of the causative medication.Conclusions: Pill-induced esophagitis commonly manifests as retrosternal chest pain, odynophagia and dysphagia, and endoscopy reveals kissing ulcer and erosion in the majority of cases. The condition can be treated with PPIs and/or antacids, and withdrawal of the offending medication.

show abstract