Drug-Induced Fever

Tabor, Patricia A.

doi:10.1177/106002808602000601

Cited by 66 publications

(71 citation statements)

References 109 publications

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“…This type of fever accounted for 70% of the drug fever observed in this series. This is also in agreement with the previous report (Tabor 1986). Furthermore, a transient elevation of serum lactic dehydrogenase may serve as an indicator of drug fever, because of its frequent association with the drug fever as shown in our study.…”

Section: Discussionsupporting

confidence: 94%

Clinical study of drug fever induced by parenteral administration of antibiotics.

Ōizumi

Onuma

Watanabe

et al. 1989

Tohoku J. Exp. Med.

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A. and MOTOMIYA, M. Clinical Study of Drug Fever Induced by Parenteral Administration of Antibiotics. Tohoku J. Exp. Med., 1989, 159 (1), [45][46][47][48][49][50][51][52][53][54][55][56] The incidence and clinical features of drug fever induced by antibiotics were investigated. Of a total of 390 patients analyzed, 193 had malignant diseases (lung cancer in most cases) and the remaining 197 had non-malignant diseases, of which the majority comprised pulmonary infectious diseases such as pneumonia, lung abscess and chronic infections. Q-Lactams most frequently induced drug fever. Piperacillin induced drug fever in 18 of 108 (17%), cefotaxime in 11 of 72 (15%), ceftizoxime in 7 of 49 (14%) and cefoperazone in 6 of 74 patients (8%). In contrast, the incidence of drug fever caused by ampicillin and that by cefazolin were in one of 39 (3%) and in none of 44 (0%), respectively. On the other hand, antimicrobial agents other than /l-lactams only rarely induced drug fever. The higher incidence of drug fever caused by newer derivatives of f3-lactam antibiotic suggests that the side chain attached to their core moiety might be involved in the mechanism of drug fever. In patients with malignancy who were on antibiotics, respiratory infection was the most frequent cause of fever exceeding 38°C. In contrast, in patients with non-malignant diseases, the use of antibiotic per se was the most frequent cause of the fever which reccurred during antibiotic therapy after a previous febrile episode had subsided. The most common feature of drug fever induced by the use of an antibiotic was as follows : A low-grade fever at the time of onset is followed by a high and remittent fever. The highest diurnal body temperature rises gradually, and then the fever subsides promptly after cessation of the causative antibiotic. The fever of this type accounted for 70% of all the drug fever in this study. A transient elevation of serum level of lactic dehydrogenase was associated with drug fever in one half (25/49, 51%) of the patients. A transient and slight decrease from the normal range in counts of neutrophils and platelets were observed in 11(23%) and in 4 (8%) of 48 patients with drug fever, respectively. These changes in laboratory findings were considered as the possible consequence of allergic processes involved in the development of drug fever and thus seem to be a helpful index for establishing the diagnosis of drug fever, drug-induced fever ; Q-lactam antibiotics ; neutrophil ; lactate dehydrogenase

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Section: Discussionsupporting

confidence: 94%

Clinical study of drug fever induced by parenteral administration of antibiotics.

Ōizumi

Onuma

Watanabe

et al. 1989

Tohoku J. Exp. Med.

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“…Fever is caused by endogenous interleukin‐1 and tumor necrosis factor‐α, which are produced in response to exogenous stimuli, and promote cyclooxygenase‐mediated prostaglandin E2 production in the arachidonic acid cascade 361. Fever is an important indicator of the presence of infection, but can also be caused by factors other than infection, such as surgery,362 blood transfusion,363 drug therapy,364, 365 and acute rejection 366. In addition, there are often multiple causes of fever in critically‐ill patients.…”

Section: Introductionmentioning

confidence: 99%

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

Nishida

Ogura

Egi

et al. 2018

Acute Medicine & Surgery

157

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Background and PurposeThe Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG 2016), a Japanese‐specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 in Japanese. An English‐language version of these guidelines was created based on the contents of the original Japanese‐language version.MethodsMembers of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ), and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two‐thirds (>66.6%) majority vote of each of the 19 committee members.ResultsA total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J‐SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation and its supporting evidence were also added to each recommendation statement. We conducted meta‐analyses for 29 CQs. Thirty seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for 5 CQs.ConclusionsBased on the evidence gathered, we were able to formulate Japanese‐specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non‐specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals.

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“…In cases of drug fever, it is observed that, in non-sensitised individuals receiving the drug for first time, the onset of fever in highly valuable and differs amongst drug classes, but most commonly appears after 7-10 day of drug administration (Patel and Gallagher, 2010;Lipsky and Hirschmann, 1981;Tabor, 1986). The patient gradually became afebrile within 48 hours of stopping all the antibiotics, even the use of antipyretics was withheld.…”

Section: Discussionmentioning

confidence: 99%

Teicoplanin induced-drug fever in a patient of complicated dengue fever

Memon¹,

Patil²

2017

Int J Recent Sci Res

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We present a case of 40 years old female, who was referred to our hospital with history of acute febrile illness with seizures, had septic shock, leukemoid reaction who was investigated and found to have dengue. Her clinical presentation was attributed to severe secondary bacterial infection. With this scenario she was empirically started on Meropenem, Teicoplanin and Doxycyclin. General condition started recovering, she became normotensive, there were no further episodes of seizure, but she continued to have persistent fever.

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Drug-Induced Fever

Cited by 66 publications

References 109 publications

Clinical study of drug fever induced by parenteral administration of antibiotics.

Clinical study of drug fever induced by parenteral administration of antibiotics.

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

Teicoplanin induced-drug fever in a patient of complicated dengue fever

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