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The incidence of drug‑induced esophagitis is 3.9 cases per 100 thousand population per year. The risk factors of its development include polypharmacy in the treatment of elderly patients and patients’ polymorbidity, supine position during and within 30 minutes after taking the drug, insufficient water intake at administration of medicinal products, intake of large tablets and/or drugs in a gelatin capsule, presence of the comorbid esophageal pathology. Drug‑induced esophageal lesions appear due to both direct toxic actions of preparations and their effects on nervous system. Pathogenesis of the drug‑induced esophagitis presents the direct irritant effect and a violation of the cytoprotective barrier of the esophageal mucosa, which is especially pronounced with prolonged contact of irritants and can lead to damage to the esophageal epithelium. Clinical symptoms of the drug‑induced esophagitis are varied and nonspecific: chest pain, heartburn, odynophagia, dysphagia, weight loss. Endoscopy is the gold standard of diagnosis, it allows revealing the esophageal lesions (erosions, bleedings, ulcers) as well as residual fragments of drugs. The diagnosis of drug‑induced esophageal lesions is often underestimated as they are often masked with gastroesophageal reflux disease and its phenotypes. The authors present data on the efficacious use of Hyalera preparation (combination of hyaluronic acid and alginate) at the drug‑induced esophagitis. The drug provides protective, anti‑inflammatory, anti‑edematous and reparative effects on the eophageal and stomach mucosa. Hyaluronic acid and alginate have a synergistic effect, reducing the severity and frequency of heartburn, regurgitation, chest pain, protecting the esophageal mucosa, relieving symptoms of the disease and improving the quality of life of patients. Hyalera proved to be an effective agent to remove symptoms of reflux‑esophagitis, caused by administration of medicinal products.
The incidence of drug‑induced esophagitis is 3.9 cases per 100 thousand population per year. The risk factors of its development include polypharmacy in the treatment of elderly patients and patients’ polymorbidity, supine position during and within 30 minutes after taking the drug, insufficient water intake at administration of medicinal products, intake of large tablets and/or drugs in a gelatin capsule, presence of the comorbid esophageal pathology. Drug‑induced esophageal lesions appear due to both direct toxic actions of preparations and their effects on nervous system. Pathogenesis of the drug‑induced esophagitis presents the direct irritant effect and a violation of the cytoprotective barrier of the esophageal mucosa, which is especially pronounced with prolonged contact of irritants and can lead to damage to the esophageal epithelium. Clinical symptoms of the drug‑induced esophagitis are varied and nonspecific: chest pain, heartburn, odynophagia, dysphagia, weight loss. Endoscopy is the gold standard of diagnosis, it allows revealing the esophageal lesions (erosions, bleedings, ulcers) as well as residual fragments of drugs. The diagnosis of drug‑induced esophageal lesions is often underestimated as they are often masked with gastroesophageal reflux disease and its phenotypes. The authors present data on the efficacious use of Hyalera preparation (combination of hyaluronic acid and alginate) at the drug‑induced esophagitis. The drug provides protective, anti‑inflammatory, anti‑edematous and reparative effects on the eophageal and stomach mucosa. Hyaluronic acid and alginate have a synergistic effect, reducing the severity and frequency of heartburn, regurgitation, chest pain, protecting the esophageal mucosa, relieving symptoms of the disease and improving the quality of life of patients. Hyalera proved to be an effective agent to remove symptoms of reflux‑esophagitis, caused by administration of medicinal products.
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