Drug-induced enterocolitis in an adult patient

Rodríguez, Raúl Rodríguez; Alfaya, Teresa; Segade, J Borja; Díaz, Y Mendez; Lozano, L Moreno; Ortega, A.; Torrijos, Elisa Gómez

doi:10.1016/j.jaip.2017.03.024

Cited by 10 publications

(15 citation statements)

References 8 publications

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“…To date, seven cases of DIES have been described, four in children, [1][2][3][4] one in an 18-year-old male patient, 5 and two in adult patients. 6,7 In 2014, Novembre et al 1 described the case of a 6-year-old girl who developed gastrointestinal symptoms of vomiting, diarrhea, pallor, and lethargy 2 hours after a drug provocation test (DPT) with amoxicillin (AMX). As the clinical and laboratory features, that is, vomiting, neutrophilia, methemoglobinemia (MethHb), and need for intravenous fluid support, resembled those of FPIES, the term DIES was proposed for the first time.…”

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Drug‐induced enterocolitis syndrome: Similarities and differences compared with food protein‐induced enterocolitis syndrome

Mori

Liccioli

Fuchs

et al. 2021

Pediatric Allergy Immunology

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Drug-induced enterocolitis syndrome (DIES) is the term used to describe reactions occurring after drug exposure. It is a non-IgEmediated hypersensitivity reaction, characterized by symptoms that typically resemble those of FPIES (food protein-induced enterocolitis syndrome). It is a rare and probably underestimated entity, since very few cases have been reported in literature so far. To date, seven cases of DIES have been described, four in children, [1][2][3][4] one in an 18-year-old male patient, 5 and two in adult patients. 6,7 In 2014, Novembre et al 1 described the case of a 6-year-old girl who developed gastrointestinal symptoms of vomiting, diarrhea, pallor, and lethargy 2 hours after a drug provocation test (DPT) with amoxicillin (AMX). As the clinical and laboratory features, that is, vomiting, neutrophilia, methemoglobinemia (MethHb), and need for intravenous fluid support, resembled those of FPIES, the term DIES was proposed for the first time. In the following, five other cases of DIES have been reported, summarized in Table 1.

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Drug‐induced enterocolitis syndrome: Similarities and differences compared with food protein‐induced enterocolitis syndrome

Mori

Liccioli

Fuchs

et al. 2021

Pediatric Allergy Immunology

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“…3,8 Concerning its age of onset, it involves mainly children, but two adult cases of 60 and 69 years old were reported. 6,7 The suspected drug was AMX in 5/10 (50%) published cases, amoxicillin-clavulanic acid (AMX-CA) in 4/10 (40%), and pantoprazole in 1/10 (10%). A confirmatory DPT was performed in 6/10 (60%) reported cases with AMX, in 3/10 (30%) with AMX-CA, and 1/10 (10%) with pantoprazole.…”

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confidence: 99%

“…Ten cases of DIES have been described so far 1‐8 . As a rare allergic disease with only a few cases reported, the prevalence of DIES is not well known 9 .…”

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confidence: 99%

“…Furthermore, the similarities and differences between DIES and FPIES have been recently underlined 3,8 . Concerning its age of onset, it involves mainly children, but two adult cases of 60 and 69 years old were reported 6,7 . The suspected drug was AMX in 5/10 (50%) published cases, amoxicillin‐clavulanic acid (AMX‐CA) in 4/10 (40%), and pantoprazole in 1/10 (10%).…”

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confidence: 99%

“…Minor criteria were as follows: 1) a second episode of repetitive vomiting after ingestion of the same drug; 2) repetitive vomiting epi- Ten cases of DIES have been described so far. [1][2][3][4][5][6][7][8] As a rare allergic disease with only a few cases reported, the prevalence of DIES is not well known. 9 However, its occurrence at the Allergy Unit of Meyer Children's University Hospital was 3/714 (0.4%) of the total cases of children referred for suspected hypersensitivity reaction from 2014…”

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The history of the drug‐induced enterocolitis syndrome

Novembre

Barni

Saretta³

et al. 2022

Pediatric Allergy Immunology

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The diagnosis of drug-induced enterocolitis syndrome (DIES), resembling the typical findings of a well-known disease, the food protein-induced enterocolitis syndrome (FPIES), was acknowledged in the first publication on the topic in 2014. Ten cases of DIES have been described so far. Unanswered questions concerning DIES include its pathogenetic mechanism, natural history, the possible presence of predisposing genetic factors, and the potential existence of its atypical forms. DIES is a recently defined and intriguing clinical entity, similar to FPIES but triggered by drugs. It seems well-defined from the clinical point of view, but its pathogenetic mechanisms are not known. DIES deserves more attention among allergists, especially among the professionals who work with children, and all efforts should be conceived to improve its correct recognition and accurate management.

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Amoxicillin/clavulanic-acid/hydrocortisone

2019

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Drug-induced enterocolitis in an adult patient

Cited by 10 publications

References 8 publications

Drug‐induced enterocolitis syndrome: Similarities and differences compared with food protein‐induced enterocolitis syndrome

Drug‐induced enterocolitis syndrome: Similarities and differences compared with food protein‐induced enterocolitis syndrome

The history of the drug‐induced enterocolitis syndrome

Amoxicillin/clavulanic-acid/hydrocortisone

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