Drug-Induced Disorders of the Nervous System

O'Connor, Kevin; Mastaglia, Frank

doi:10.1016/b978-0-12-407710-2.00032-1

Cited by 5 publications

(3 citation statements)

References 215 publications

(202 reference statements)

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“…Management of patients with inadvertent drug injection varies based on the type and dosage of different drugs and unknown intrathecal complications. The most impor-tant principle in the management of these patients is to pay attention to hemodynamic stability and cerebrospinal fluid (CSF) lavage (9)(10)(11). A standard CSF lavage consists of about 10 to 20 mL of CSF fluid, which is gently withdrawn through a needle or catheter and replaced with preservative-free normal saline (12).…”

Section: Discussionmentioning

confidence: 99%

Accidental Intrathecal Injection of Etomidate During Spinal Anesthesia: A Case Report

Sehat

Ahmadi

2023

Anesth Pain Med

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: Etomidate is an ultra-short-acting anesthetic agent derived from imidazole that can only be administered intravenously. Etomidate has excellent hemodynamic properties in inducing anesthesia, making it an ideal choice for patients with shock, hypovolemia, or significant cardiovascular disease, with minimal reduction in blood pressure. We report a case of a female patient who was given accidental etomidate intrathecally instead of ropivacaine because of its similar appearance, which led to a slight decrease in blood pressure and no change in the pulse rate. The patient had stable vital signs and no neurological complications.

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Section: Discussionmentioning

confidence: 99%

Accidental Intrathecal Injection of Etomidate During Spinal Anesthesia: A Case Report

Sehat

Ahmadi

2023

Anesth Pain Med

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“…Des Weiteren werden ASA bei Anästhetika, Antiarrhythmika, Anticholinergika, Antidiabetika, Antimykotika, antineoplastischen Medikamenten, antiviraler Medikation, Immunsuppressiva und bei Opioiden sowie Theophyllin beschrieben. Für eine ausführliche Aufstellung wird auf das entsprechende Buchkapitel in "Animoffs Neurology and General Medicine" verwiesen [57].…”

Section: Sonstige Medikamenteunclassified

Akut symptomatische Anfälle bei internistischen Erkrankungen und Noxen

2021

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ZusammenfassungAkut symptomatische Anfälle sind definiert durch einen engen zeitlichen Zusammenhang zwischen einem akuten Ereignis, welches einen negativen Einfluss auf das Gehirn hat, und dem daraus resultierenden Auftreten von epileptischen Anfällen. Diesem akuten Ereignis können neben einer strukturellen Hirnschädigung (z. B. traumatisch, vaskulär) unter anderem auch Entgleisungen im Rahmen internistischer Erkrankungen oder Einfluss von externen Noxen wie Medikamenten, Alkohol oder Drogen zugrunde liegen. In weiterer Folge beschreiben wir die häufigsten internistischen Ursachen, welche zu akut symptomatischen Anfällen führen können. Das Risiko von Elektrolytentgleisungen, Leber- und Nierenerkrankungen, Darmerkrankungen, Diabetes mellitus und der Einfluss unterschiedlicher Medikamente wird diskutiert.

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“…Xanthene derivatives are still an attractive research field for both academia investigations and industry [18]. Xanthenes are very important compounds with tremendous biological applications, such as antispasmodic [19], antiparkinsonian [20], and antipsychotic ones [20]. They are also used in the treatment of urinary incontinence [21] and bronchitis [22].…”

Section: Introductionmentioning

confidence: 99%

4a′-Hydroxy-3′,3′,5,6′,6′,7-hexamethyl-3′,4′,4a′,6′,7′,9a′-hexahydrospiro[indole-3,9′-xanthene]-1′,2,8′(1H,2′H,5′H)-trione

Ryzhkova,

Kalashnikova,

Ryzhkov

et al. 2023

Molbank

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Pseudo-multicomponent reactions (Pseudo-MCRs) have led to a variety of compounds with interesting biological properties, especially desirable in the pharmaceutical industry. The isatin nucleus could be considered a privileged scaffold for the design of biologically active substances. Dimedone is an interesting and versatile molecule for most organic transformations, especially one-pot and multicomponent reactions. Xanthene derivatives are still an attractive research field for both academia investigations and industry. In this investigation, a simple and efficient tandem Knoevenagel–Michael protocol with subsequent cyclization for the synthesis of the previously unknown 4a’-hydroxy-3′,3′,5,6′,6′,7-hexamethyl-3′,4′,4a’,6′,7′,9a′-hexahydrospiro[indole-3,9′-xanthene]-1′,2,8′(1H,2′H,5′H)-trione was elaborated. The suggested method is based on the pseudo-MCR of 5,7-dimethylisatin and dimedone. The structure of the earlier unknown compound was proven using 1H, 13C-NMR, and IR spectroscopy, mass spectrometry, and elemental analysis. To compare the developed protocol with the existing ones, unsubstituted spiro[indole-3,9′-xanthene] was synthesized. Its structure has been proven using two-dimensional (2D) NMR spectroscopy techniques.

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Drug-Induced Disorders of the Nervous System

Cited by 5 publications

References 215 publications

Accidental Intrathecal Injection of Etomidate During Spinal Anesthesia: A Case Report

Accidental Intrathecal Injection of Etomidate During Spinal Anesthesia: A Case Report

Akut symptomatische Anfälle bei internistischen Erkrankungen und Noxen

4a′-Hydroxy-3′,3′,5,6′,6′,7-hexamethyl-3′,4′,4a′,6′,7′,9a′-hexahydrospiro[indole-3,9′-xanthene]-1′,2,8′(1H,2′H,5′H)-trione

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