Drug induced aseptic meningitis: A diagnostic challenge

Frank-Briggs, AI; Oluwatade, OJ

doi:10.4314/njp.v41i2.13

Cited by 6 publications

(12 citation statements)

References 9 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To our knowledge, there are only two published case reports of NSAIDs-induced aseptic meningitis that presented at pediatric age, caused by ibuprofen 3 and rofecoxib, 11 respectively. We summarize clinical and laboratorial features on Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…DIAM is suspected by the establishment of a temporal relationship between the administration of the drug and the onset of symptoms. Latency period is short, typically less than 48 hours 3 . There is a rapid resolution of symptoms after drug withdrawal, one to five days 4 …”

Section: Discussionmentioning

confidence: 99%

“…DIAM can occur in patients that previously tolerated the offending drug 3 6 Prior exposures to the drug have been noted in 35% of patients with ibuprofen-induced meningitis 4 .…”

Section: Discussionmentioning

confidence: 99%

“…Drug-induced aseptic meningitis (DIAM) is a rare entity and constitutes a diagnosis and patient management challenge. The most commonly responsible drugs are nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, immunosuppressive-immunomodulatory, antiepileptic and intrathecal drugs 3 4 …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ibuprofen-Induced Aseptic Meningitis: A Case Report

Pires

Lemos²,

Pereira³

et al. 2019

Rev. paul. pediatr.

View full text Add to dashboard Cite

Objective: To report a case of a male adolescent with the diagnosis of ibuprofen-induced meningitis. We discuss themain causes of drug-induced aseptic meningitis (DIAM) and highlight the importance of early recognition of DIAM, sothat the offending drug can be withdrawn, and recurrences prevented. Only few DIAM cases have been reported in pediatric age.Case description: A healthy 15-year-old boy presented to the emergency department with headache, nausea, dizziness, fever, conjunctival hyperemia and blurred vision 30 minutes after ibuprofen-intake. During his stay, he developed emesis and neck stiffness. Cerebrospinal ﬂuid analysis excluded infectious causes, and DIAM was considered. He totally recovered after drug withdrawal.Comments: DIAM is a rare entity, that should be considered in the differential diagnosis of an aseptic meningitis. The major causative agents are nonsteroidal anti-inflammatory drugs, particularly ibuprofen. Suspicion is made by the chronologic link between drug intake and the beginning of symptoms, but infectious causes should always be ruled out.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…DIAM can occur in patients that previously tolerated the offending drug 3 6 Prior exposures to the drug have been noted in 35% of patients with ibuprofen-induced meningitis 4 .…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ibuprofen-Induced Aseptic Meningitis: A Case Report

Pires

Lemos²,

Pereira³

et al. 2019

Rev. paul. pediatr.

View full text Add to dashboard Cite

show abstract

“…Âîçìîaeíî òðàíçèòîðíîå ñíèaeåíèå îñòðîòû ñëóõà ïðè ïðè¸ìå ÀÑÊ, èíäîìåòàöèíà, èáóïðîôåíà è ïðåïàðàòîâ ãðóïïû ïèðàçîëîíà. Ïîñëå óïîòðåáëåíèÿ íåñêîëüêèõ ïðåïàðàòîâ îïèñàíî ðàçâèòèå àñåïòè÷åñêîãî ìåíèíãèòà: îòìå-÷àåòñÿ âûñîêàÿ êîððåëÿöèÿ çàáîëåâàíèÿ ñ ïðèåìîì èáóïðîôåíà, íåâûñîêàÿ -ñ ïðèåìîì íàïðîêñåíà, äèêëîôåíàêà, ðîôåêîêñèáà, ñëàáàÿ -ñ ïðèåìîì êåòîïðîôåíà, ñàëèöèëàòîâ, ïèðîêñèêàìà, öåëåêîêñèáà [24].…”

Section: òå÷åíèå áåðåìåííîñòè è çàìåäëåíèå ðîäîâîé äåÿòåëüíîñòèunclassified

Нестероидные Противовоспалительные Средства: Ключевые Механизмы Действия И Нейропротективный Потенциал

Кутяков¹,

Шадрина²,

Труфанова³

et al. 2019

Эксп. и клин. фармакол.

View full text Add to dashboard Cite

Нестероидные противовоспалительные средства (НПВС) применяются для купирования болевого синдрома при многочисленных патологических состояниях — головной, зубной, мышечной боли, а также для лечения воспалительных процессов и в качестве жаропонижающих препаратов. Противовоспалительный и анальгезирующий эффекты взаимосвязаны, при этом противовоспалительный эффект доминирует. Основным механизмом действия НПВС является ингибирование биосинтеза простагландинов (ПГ), участвующих в развитии воспаления и болевого синдрома. Влиянием на синтез ПГ обусловлен основной побочный эффект НПВС — ульцерогенное действие. В настоящее время поиск новых НПВС направлен на минимизацию нежелательных реакций при сохранении всех основных фармакологических эффектов. Целью обзора являлись: 1) оценка и анализ перечня применяющихся в РФ НПВС, механизм действия, показания к их применению, возможные нежелательные эффекты, молекулярные, клеточные и функциональные мишени действия НПВС, возможности и перспективы поиска новых безопасных средств, обладающих противовоспалительной активностью; 2) характеристика особенности реализации эффектов ПНВС в центральной нервной системе.

show abstract

A Rare Complication of Trimethoprim-Sulfamethoxazole: Drug Induced Aseptic Meningitis

Jha

Stromich

Cohen

et al. 2016

Case Reports in Infectious Diseases

View full text Add to dashboard Cite

Drug induced aseptic meningitis is a rare but challenging diagnosis, most commonly reported with nonsteroidal anti-inflammatory drugs and antibiotics. Trimethoprim/sulfamethoxazole is a sulfonamide that is widely used in clinical practice for the treatment and prophylaxis of various infections. Drug induced aseptic meningitis, when seen with trimethoprim/sulfamethoxazole, occurs predominantly in patients with some degree of immune compromise and is less commonly seen in immune competent individuals. The patient often exhibits the classic symptoms of meningitis. Early diagnosis is important, since the cessation of the antibiotic leads to rapid clinical improvement. Trimethoprim/sulfamethoxazole induced aseptic meningitis has been underreported to FDA/MED-WATCH program. Here we report two cases of trimethoprim/sulfamethoxazole: an immune competent individual and immune compromised individual, both of which presented with signs of meningitis and a negative infectious workup. Trimethoprim/sulfamethoxazole is an uncommon and mysterious adverse reaction to a commonly used antibiotic. It should be considered in the differential diagnosis of patients presenting with acute signs and symptoms of meningitis especially after infectious causes have been ruled out.

show abstract

Drug induced aseptic meningitis: A diagnostic challenge

Cited by 6 publications

References 9 publications

Ibuprofen-Induced Aseptic Meningitis: A Case Report

Ibuprofen-Induced Aseptic Meningitis: A Case Report

Нестероидные Противовоспалительные Средства: Ключевые Механизмы Действия И Нейропротективный Потенциал

A Rare Complication of Trimethoprim-Sulfamethoxazole: Drug Induced Aseptic Meningitis

Contact Info

Product

Resources

About