Drug‐induced accelerated nodulosis: review of the literature

Palmeiro, Ana Gusmão; Lourenço, Maria Helena; Catarino, Alexandre Miroux; Crispim, Inês; Branco, Jaime; Viana, Isabel

doi:10.1111/ijd.16549

Cited by 2 publications

(1 citation statement)

References 43 publications

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“…Interestingly, this condition develops even when RA disease activity is well controlled and can occur without pre-existing RNs [38]. Since its initial discovery, accelerated rheumatoid nodulosis has also been linked to treatment with other medications such as leflunomide, etanercept, azathioprine, tocilizumab, letrozole, and infliximab anti-TNF-α therapy [35,39].…”

Section: Accelerated Rheumatoid Nodulosismentioning

confidence: 99%

Cutaneous Manifestations of Rheumatoid Arthritis: Diagnosis and Treatment

Diaz,

Natarelli,

Wei

et al. 2023

JPM

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Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disorder characterized by inflammatory arthritis and periarticular structural damage. Available evidence suggests that RA results from complex interactions between genetic susceptibility (e.g., HLA-DRB1), environmental factors (e.g., smoking), and immune dysregulation. Alongside joint-related symptoms, individuals with RA may also experience a wide array of skin issues, including the development of nodules, neutrophilic dermatoses, vasculitis, and vasculopathy. Treatment strategies for these manifestations vary but routinely involve corticosteroids, disease-modifying anti-rheumatic drugs, and biologics, with individualized approaches guided by disease severity. In this review, we provide comprehensive insights into the skin-related issues associated with RA, outlining their clinical characteristics and histopathological findings. Our aim is to facilitate early diagnosis and personalized treatment to improve the quality of life of affected individuals.

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Section: Accelerated Rheumatoid Nodulosismentioning

confidence: 99%

Cutaneous Manifestations of Rheumatoid Arthritis: Diagnosis and Treatment

Diaz,

Natarelli,

Wei

et al. 2023

JPM

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Subcutaneous Nodules as Manifestations of Systemic Disease

Rothschild

2024

Rheumato

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The spectrum of disorders/phenomena encompassed in the practice of rheumatology is quite broad. In addition, our expertise is typically sought whenever other physicians encounter phenomena outside their knowledge base. While skin alterations typically prompt referrals to dermatology practices, alterations underlying the skin (e.g., subcutaneous) may well represent localization in “no man’s land” or an orphaned localization, with rheumatology thus referred as to the specialty of last resort—one of the roles that rheumatology has fulfilled for more than half a century. The current review addresses the cacophony of disorders producing or associated with variouslysized subcutaneous nodules. Their classifications, while necessarily artificial, encompass the full spectrum of pathologic processes. They are delineated in the current style to facilitate the consideration required to distinguish among them and to facilitate recognize the underlying processes for which we as rheumatologists are renowned.

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Drug‐induced accelerated nodulosis: review of the literature

Cited by 2 publications

References 43 publications

Cutaneous Manifestations of Rheumatoid Arthritis: Diagnosis and Treatment

Cutaneous Manifestations of Rheumatoid Arthritis: Diagnosis and Treatment

Subcutaneous Nodules as Manifestations of Systemic Disease

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