Drug hydroxylator phenotype in Hungary

Szorady, I; Sánta, A

doi:10.1007/bf00607584

Eur J Clin Pharmacol

1987

DOI: 10.1007/bf00607584

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Drug hydroxylator phenotype in Hungary

I Szorady

A Sánta

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Cited by 7 publications

(1 citation statement)

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“…Nevertheless, in this worldwide reconstruction of human evolution, some European populations (Basques, Finns, Hungarians and Estonians) seem to differ both genetically and linguistically from the others. Previous studies of polymorphic drug metabolism among Hungarians (Szorady & Santa 1987) and Finns (Syvalahti et al 1986;Arvela et nl. 1988) were limited to debrisoquine hydroxylation phenotyping and did not reveal significant differences from the average European population (Alvan et al 1990).…”

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confidence: 96%

Polymorphism of Debrisoquine and Mephenytoin Hydroxylation among Estonians

Kiivet

Svensson

Sjöqvist

1993

Pharmacology & Toxicology

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Debrisoquine and S-mephenytoin hydroxylation polymorphisms were studied in 156 unrelated native Estonians. The hydroxylation phenotypes were assessed by coadministration of mephenytoin with debrisoquine or dextromethorphan. The frequency of the poor metaboliser phenotype of debrisoquine/dextromethorphan was 4.5% (95% confidence interval 1.2-7.8%), and that of mephenytoin was 3.9% (95% confidence interval 0.9-6.9%) among Estonians, which is very similar to what has been reported in other Caucasian populations.

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mentioning

confidence: 96%

Polymorphism of Debrisoquine and Mephenytoin Hydroxylation among Estonians

Kiivet

Svensson

Sjöqvist

1993

Pharmacology & Toxicology

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Polymorphism of debrisoquine oxidation in New Zealand Caucasians

Wanwimolruk

Denton

Ferry

et al. 1992

Eur J Clin Pharmacol

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Dextromethorphan O-demethylation polymorphism in Jordanians

Irshaid

Al-Hadidi

Rawashdeh

1993

Eur J Clin Pharmacol

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The O-demethylation of dextromethorphan (DMT) to dextrorphan (DRP) was studied in 241 unrelated, healthy Jordanian volunteers (171 males, 70 females). Urine was collected for 8 h following a single oral dose of DMT bromhydrate 30 mg. A thin-layer chromatographic (TLC) technique was used to identify the metaboliser phenotype. The frequency of the poor metaboliser phenotype was found to be 2.9% (approximate 95% confidence interval 0.8-5.0%). Applying the Hardy-Weinberg Law, the frequency of the recessive autosomal gene controlling poor metabolism was 0.17 (95% confidence interval 0.108-0.232).

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Drug hydroxylator phenotype in Hungary

Cited by 7 publications

References 5 publications

Polymorphism of Debrisoquine and Mephenytoin Hydroxylation among Estonians

Polymorphism of Debrisoquine and Mephenytoin Hydroxylation among Estonians

Polymorphism of debrisoquine oxidation in New Zealand Caucasians

Dextromethorphan O-demethylation polymorphism in Jordanians

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