Drug free anti-cell proliferative and anti-platelet adhesion coating for vascular stents via polymeric electrospun fibers

Chalony, Carmen; Aguilar, Ludwig Erik; Park, Chan Hee; Kim, Cheol Sang

doi:10.1016/j.matlet.2021.129545

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…However, the incidence of restenosis after implantation reaches nearly 34%, and restenosis has become the main factor restricting the development of PTCA [2][3][4]. The preparation of the drug coating on the stent surface inhibits the transition proliferation of smooth muscle cells through drug sustained release, which has become an effective method for the treatment of restenosis [5][6][7][8]. Poly lactic-co-glycolic acid (PLGA) has shown broad applicability as a drug carrier because of its reliable safety, excellent biocompatibility, and controllable biodegradability.…”

Section: Introductionmentioning

confidence: 99%

PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility

Jia

Zhang

2021

Coatings

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PLGA (Poly lactic-co-glycolic acid) and PLGA drug-loading coatings were prepared on 316 L stainless steel by electrostatic spray deposition (ESD). The surface morphology, three-dimensional morphology, and crystal structures of the coatings were observed by scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray diffraction (XRD). Thermal properties, molecular weight, and coating composition were studied by differential scanning calorimetry (DSC), gel permeation chromatography (GPC), and NMR. The degradation behaviors of the coatings were studied by mass changes, relative molecular mass and distributions, polymer compositions, thermal properties, and surface morphologies. The blood compatibilities of the coatings were investigated by platelet adhesion testing and dynamic coagulation times. SEM results indicated the drug-loading coating with 33% RAPA had the smoothest and most compact morphology. Addition of RAPA decreased the Tg of the PLGA coating, accompanied by partial crystallization that slowed the degradation rate of the drug-loaded coating. Microscopically, the morphology of the PLGA drug-loaded coating was coarser than the PLGA coating. The average surface roughness values of line and surface scannings were 16.232 nm and 39.538 nm, respectively. The surface of the drug-loading coating was micro uneven, and the macro smooth and micro multiphase separation structure helped improve its blood compatibility.

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Section: Introductionmentioning

confidence: 99%

PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility

Jia

Zhang

2021

Coatings

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Characterization, mechanical and biomedical properties of titanium oxynitride coating

Buranich

Pogrebnjak

Pogorielov

et al. 2023

Ceramics International

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Electrospinning of Potential Medical Devices (Wound Dressings, Tissue Engineering Scaffolds, Face Masks) and Their Regulatory Approach

Uhljar

Ambrus

2023

Pharmaceutics

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Electrospinning is the simplest and most widely used technology for producing ultra-thin fibers. During electrospinning, the high voltage causes a thin jet to be launched from the liquid polymer and then deposited onto the grounded collector. Depending on the type of the fluid, solution and melt electrospinning are distinguished. The morphology and physicochemical properties of the produced fibers depend on many factors, which can be categorized into three groups: process parameters, material properties, and ambient parameters. In the biomedical field, electrospun nanofibers have a wide variety of applications ranging from medication delivery systems to tissue engineering scaffolds and soft electronics. Many of these showed promising results for potential use as medical devices in the future. Medical devices are used to cure, prevent, or diagnose diseases without the presence of any active pharmaceutical ingredients. The regulation of conventional medical devices is strict and carefully controlled; however, it is not yet properly defined in the case of nanotechnology-made devices. This review is divided into two parts. The first part provides an overview on electrospinning through several examples, while the second part focuses on developments in the field of electrospun medical devices. Additionally, the relevant regulatory framework is summarized at the end of this paper.

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Drug free anti-cell proliferative and anti-platelet adhesion coating for vascular stents via polymeric electrospun fibers

Cited by 3 publications

References 6 publications

PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility

PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility

Characterization, mechanical and biomedical properties of titanium oxynitride coating

Electrospinning of Potential Medical Devices (Wound Dressings, Tissue Engineering Scaffolds, Face Masks) and Their Regulatory Approach

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