Drug Fever

Cluff, Leighton E.; Johnson, J. E.

doi:10.1159/000391364

Cited by 11 publications

(15 citation statements)

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“…The largely negative results in patients with drug fever without rashes in this study raise the question of whether the fever is immunologically mediated in these cases. There is substantial evidence that fever can occur as a feature of immunologic reactions in some cir cumstances [6], but possibly other mechanisms are responsible for the temperature elevation in some of these patients.…”

Section: Discussionmentioning

confidence: 99%

Experience with Lymphocyte Transformation Tests in Evaluating Allergy to Aminosalicylic Acid, Isoniazid and Streptomycin

Mathews

Pan

Wells

1972

Int Arch Allergy Immunol

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Patients with possible allergic reactions to aminosalicylic acid, isoniazid or streptomycin were systematically evaluated to ascertain circumstances under which in vitro transformation of their lymphocytes cultured with the suspected drug would and would not be observed. Leukocytes were cultured for 6 days with 1,000, 100 and 10 µg of drug/ml and tritiated thymidine uptake determined. Stimulation was observed in 13 of 53 cultures from 39 patients and in only 1 of 45 control cultures of lymphocytes from persons who had taken these drugs without evident adverse effects. Optimal drug concentration was variable. In correlating lymphocyte culture results with clinical information, it was found that individuals experiencing predominantly febrile drug reactions usually had negative cultures. In general, lymphocyte transformation does not necessarily indicate immunologic responsiveness of a deleterious type, but in this study there was a significant empiric correlation with clinical drug allergy.

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Section: Discussionmentioning

confidence: 99%

Experience with Lymphocyte Transformation Tests in Evaluating Allergy to Aminosalicylic Acid, Isoniazid and Streptomycin

Mathews

Pan

Wells

1972

Int Arch Allergy Immunol

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“…These postulated events are presented diagrammatically in Fig. 12.18 Finally, these observations on tuberculin-induced fever suggest that the release of EP from specifically sensitized blood cells, incubated in vitro with antigen, may be a sensitive technique for the investigation of other allergic conditions associated with fever (50). …”

Section: Response Of Normal Rabbits Injected Intravenously With Mixtumentioning

confidence: 97%

Studies on Tuberculin Fever

Atkins

Heijn

1965

The Journal of Experimental Medicine

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Although fever is a well known and common manifestation of hypersensitivity, little has been learned about the sequence of events by which antigen disturbs temperature regulation in sensitized individuals. Using tuberculininduced fever in rabbits infected with BCG as a model, we have shown in previous papers that an endogenous pyrogen (EP) appears in the circulation of such animals during the febrile response (1, 2). When injected intravenously this agent causes immediate fevers in normal rabbits, and is, therefore, clearly distinct from tuberculin itself which produces fever after a latency of 45 to 60 minutes and is pyrogenic only in animals previously sensitized by BCG. The tissue source of EP in this form of hypersensitivity fever has remained uncertain. In several systems of hypersensitivity, including tuberculin, Johanovsk~ has reported that when antigen is added in vitro to mononuclear ceils from spleen or lymph nodes of specifically sensitized animals, a pyrogen is formed which he has called 'hypersensitivity pyrogen' to distinguish it from serum endogenous pyrogen present in other experimental fevers (3-8).In the following experiments, tuberculin was added in vitro to various tissues of BCG-sensitized rabbits in an attempt to repeat Johanovskg's findings and to determine the origin of the pyrogen which appears in the serum in tuberculin-induced fever. Johanovsk~'s observations were not confirmed, and evidence is presented instead that sensitized blood cells release EP in vitro when incubated with tuberculin and hence may be a source of the circulating pyrogen in this form of hypersensitivity fever.In additional experiments, it was found that normal blood cells, briefly incubated in plasma of sensitized animals, were similarly activated in vitro by tuberculin, an observation which suggests that humoral antibodies play a role in the genesis of tuberculin-induced fever.

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“…The immunological mediators and mechanisms of allergic drug fever in man have not been identified. The reader is referred to Cluff's recent review (93) for further discussion.…”

Section: Immunopathological Mechanisms Of Drug Allergymentioning

confidence: 99%

Immunochemical Mechanisms of Drug Allergy

Levine¹

1966

Annu. Rev. Med.

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Drug Fever

Cited by 11 publications

References 0 publications

Experience with Lymphocyte Transformation Tests in Evaluating Allergy to Aminosalicylic Acid, Isoniazid and Streptomycin

Experience with Lymphocyte Transformation Tests in Evaluating Allergy to Aminosalicylic Acid, Isoniazid and Streptomycin

Studies on Tuberculin Fever

Immunochemical Mechanisms of Drug Allergy

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