Drug eruption in a cat resembling pemphigus foliaceus

McEwan, Neil; McNeil, P. E.; Kirkham, D.; Sullivan, Martin

doi:10.1111/j.1748-5827.1987.tb01288.x

Cited by 29 publications

(22 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A case of systemic vasculitis with cutaneous involvement was reported in a cat after having received fenbendazole 15 and another cat was reported to have developed cutaneous vasculitis as a result of oral cimetidine administration. 16…”

Section: Drugsmentioning

confidence: 99%

Cutaneous Vasculitis in Small Animals

Innerå¹

2013

Veterinary Clinics of North America: Small Animal Practice

View full text Add to dashboard Cite

Cutaneous vasculitis is an inflammatory process targeting blood vessels. Underlying factors include drugs, infectious diseases, adverse reactions to food, malignancies, and immune-mediated diseases. Vasculitis is a reaction pattern warranting a workup to identify triggers. Presenting symptoms include purpura, pitting edema, and skin ulcerations. Constitutional signs include fever, depression, and anorexia and seem to be present in the majority of patients. Once a diagnosis is confirmed, treatment and follow-up must be tailored to the individual. High-dose immunosuppressive medications are only recommended once infectious diseases capable of producing a similar constellation of clinical signs have been ruled out.

show abstract

Section: Drugsmentioning

confidence: 99%

Cutaneous Vasculitis in Small Animals

Innerå¹

2013

Veterinary Clinics of North America: Small Animal Practice

View full text Add to dashboard Cite

show abstract

“…drug‐triggered pemphigus) 24 . Cases of drug‐related PF have been suspected in several dogs and rare cats for 20 years 9,25–29 . A recent paper provided information on four additional patients 30 .…”

Section: Pemphigus Foliaceusmentioning

confidence: 99%

“…To evaluate the probability of association between the administration of a medication and the development of a particular event, an assessment of likelihood of drug reaction must be made using ‘adverse drug reaction probability scales’ such as the one developed years ago by Naranjo et al 32 . When this scale is applied to all previous cases of putative drug‐related pemphigus in dogs and cats 25–30 only low scores interpreted as ‘possible’ probabilities of drug reaction are obtained. Therefore, at this time, the strength of evidence supporting drug causation for rare cases of PF in dogs and cats is weak at best, and further documentation of canine and feline cases with highly probable drug‐related PF is critically needed.…”

Section: Pemphigus Foliaceusmentioning

confidence: 99%

A review of autoimmune skin diseases in domestic animals: I – Superficial pemphigus

Olivry

2006

Veterinary Dermatology

158

View full text Add to dashboard Cite

In humans, the pemphigus denomination encompasses a group of autoimmune blistering skin diseases with intraepidermal separation resulting from cell-cell detachment by acantholysis. Entities are classified based on the level of blistering in the epidermis, and both superficial (pemphigus foliaceus, IgA pemphigus) and deep (pemphigus vulgaris, pemphigus vegetans and paraneoplastic pemphigus) variants are recognized. In domestic animals, subsets of pemphigus have been recognized since the mid-1970s, and the disease classification resembles that used for human patients. This article reviews up-to-date knowledge on the epidemiology, clinical signs, histopathology, immunopathology and treatment outcome of superficial pemphigus in domestic animals. Detailed information on canine, feline, equine and caprine pemphigus foliaceus, canine and feline pemphigus erythematosus and canine panepidermal pustular pemphigus is provided.

show abstract

“…Histopathological evaluation with exclusion of infectious aetiologies confirms PF in a variety of species, including humans, dogs, cats, horses, goats and sheep . To date, comparatively fewer studies have described the pathophysiology, clinical course and treatment outcomes of PF in cats relative to humans and dogs . Similarly, little has been published regarding the impact of PF and its management on the quality of life (QoL) of cats and their owners .…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological findings and clinical outcomes in 49 cases of feline pemphigus foliaceus examined in Northern California, USA (1987–2017)

Jordan

Affolter

Outerbridge

et al. 2019

Veterinary Dermatology

View full text Add to dashboard Cite

Background -Few studies have described the pathophysiology, clinical course, treatment outcomes and quality of life (QoL) of cats with pemphigus foliaceus (PF). Objective -Describe clinicopathological features, treatment outcomes and impacts on QoL in feline PF.Animals -Forty-nine client-owned cats with PF that presented to a veterinary teaching hospital between 1987 and 2017.Methods and materials -Medical records and histopathological reports were reviewed to obtain clinicopathological data and treatment outcomes. Owners were contacted and requested to complete a questionnaire to obtain long-term follow-up and evaluate the impacts of PF on QoL of cats and owners.Results -Domestic short/medium/long hair breeds were most commonly affected, with pinnae, head, haired face, nasal planum and ungual folds most frequently involved. Associated pruritus and systemic signs of illness were common. Vasculopathological changes were noted in a small proportion of cats. Corticosteroid monotherapy was sufficient to induce complete remission in the majority of cats. Pemphigus foliaceus and its management had a negative impact on QoL of both cats and owners. Receiving/administering medications, attending veterinary appointments, and financial and time commitments were cited sources of stress for affected cats and/or owners.Conclusions and clinical importance -Results illustrate that affected cats generally respond favourably to treatment but do require long-term therapy. The exact aetiology of the vasculopathological changes was unclear; it may reflect the stage or severity of disease or suggest the presence of a cutaneous adverse drug reaction. Clinicians managing cats with PF should be aware of the potential negative impact on QoL of owners and cats and adjust management accordingly. Case selection criteriaAn electronic search of the computerized medical records of the veterinary teaching hospital was performed to identify cats diagnosed

show abstract

Drug eruption in a cat resembling pemphigus foliaceus

Cited by 29 publications

References 12 publications

Cutaneous Vasculitis in Small Animals

Cutaneous Vasculitis in Small Animals

A review of autoimmune skin diseases in domestic animals: I – Superficial pemphigus

Clinicopathological findings and clinical outcomes in 49 cases of feline pemphigus foliaceus examined in Northern California, USA (1987–2017)

Contact Info

Product

Resources

About