Drug-encapsulated carbon (DECON): A novel platform for enhanced drug delivery

Yadavalli, Tejabhiram; Ames, Joshua; Agelidis, Alex; Suryawanshi, Rahul K.; Jaishankar, Dinesh; Hopkins, James; Thakkar, Neel; Koujah, Lulia; Shukla, Deepak

doi:10.1126/sciadv.aax0780

Cited by 51 publications

(40 citation statements)

References 47 publications

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“…Restasis®from Allergan (Irvine, CA, USA) is a 0.05% CyA anionic emulsion, containing castor oil and polysorbate 80 as emulsifying agent, and was launched on the United States market before 2012, while Ikervis®(Santen Oy, Tampere, Finland), a 0.1% CyA stable cationic nanoemulsion based on Nanosorb®technology, was granted marketing authorisation by the European Commission (EC) for treatment of severe keratitis in adult patients with DED only after 2015. These commercial products result from many attempts done by using different strategies, still in continuous development, such as prodrugs [12], liposomes [13], nanoparticles [14], nanosphere [15], solid lipid nanoparticles [16][17][18], contact lenses [19], ocular inserts [20,21], implants [22] and emulgel [23]. Each of these techniques has contributed to solve various critical issues such as cytotoxicity, low precorneal residence time after ocular instillation with reduced bioavailability and low solubility.…”

Section: Introductionmentioning

confidence: 99%

Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano) for Ocular Delivery of Cyclosporine-A

et al. 2020

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The physiological protective mechanisms of the eye reduce the bioavailability of topically administered drugs above all for those with high molecular weight and /or lipophilic characteristics, such as Cyclosporine A (CyA). The combined strategy based on the association of nanomicelles and mucoadhesive polymer seems promising since a limited number of commercial products containing CyA have been recently approved. The scope of this investigation was the design of Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano), based on a binary system of two surfactants in combination with hyaluronic acid, and their biopharmaceutical evaluation. The optimisation of the ASMP-Nano in term of the amount of surfactants, CyA-loading and size determined the selection of the clear and stable Nano1HAB-CyA formulation containing 0.105% w/w CyA loaded-nanomicelles with a size of 14.41 nm. The nanostructured system had a protective effect towards epithelial corneal cells with a cell viability of more than 80%. It interacted with cellular barriers favouring the uptake and the accumulation of CyA into the cells as evidenced by fluorescent probe distribution, by hindering CyA permeation through reconstituted corneal epithelial tissue. In pharmacokinetics study on rabbits, the nanomicellar carrier prolonged the CyA retention time in the precorneal area mainly in presence of hyaluronic acid (HA), a mucoadhesive polymer.

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Section: Introductionmentioning

confidence: 99%

Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano) for Ocular Delivery of Cyclosporine-A

et al. 2020

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“…This kinase inhibitor is being considered at par with trifluorothymidine (TFT), which is the currently prescribed therapeutic for ocular herpes (Jaishankar et al, 2018). Yadavalli et al (2019) have found activated carbon particles to be efficient acyclovir (ACV)-drug delivery systems that trapped the virions within themselves. Zinc oxide micro-nanoparticles and nanowires can inhibit HSV-1 entry as well (Antoine et al, 2012;Trigilio et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Herpes Simplex Virus: The Hostile Guest That Takes Over Your Home

2020

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Alpha (α)-herpesviruses (HSV-1 and HSV-2), like other viruses, are obligate intracellular parasites. They hijack the cellular machinery to survive and replicate through evading the defensive responses by the host. The viral genome of herpes simplex viruses (HSVs) contains viral genes, the products of which are destined to exploit the host apparatus for their own existence. Cellular modulations begin from the entry point itself. The two main gateways that the virus has to penetrate are the cell membrane and the nuclear membrane. Changes in the cell membrane are triggered when the glycoproteins of HSV interact with the surface receptors of the host cell, and from here, the components of the cytoskeleton take over. The rearrangement in the cytoskeleton components help the virus to enter as well as transport to the nucleus and back to the cell membrane to spread out to the other cells. The entire carriage process is also mediated by the motor proteins of the kinesin and dynein superfamily and is directed by the viral tegument proteins. Also, the virus captures the cell's most efficient cargo carrying system, the endoplasmic reticulum (ER)-Golgi vesicular transport machinery for egress to the cell membrane. For these reasons, the host cell has its own checkpoints where the normal functions are halted once a danger is sensed. However, a cell may be prepared for the adversities from an invading virus, and it is simply commendable that the virus has the antidote to these cellular strategies as well. The HSV viral proteins are capable of limiting the use of the transcriptional and translational tools for the cell itself, so that its own transcription and translation pathways remain unhindered. HSV prefers to constrain any self-destruction process of the cell-be it autophagy in the lysosome or apoptosis by the mitochondria, so that it can continue to parasitize the cell for its own survival. This review gives a detailed account of the significance of compartmentalization during HSV pathogenesis. It also highlights the undiscovered areas in the HSV cell biology research which demand attention for devising improved therapeutics against the infection.

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“…Yadavalli et al [133] have explored the potential of highly porous activated carbon (HPAC) particles as a model for restricting HSV-1 and HSV-2 from entering target cells. They have considered this material due to the charcoal surface-active that could provide antiviral effects through virion sequestration approach.…”

Section: Nano-based Antiviral Agents Against Herpes Virusesmentioning

confidence: 99%

Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers

et al. 2020

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Viral infections are a major global health problem, representing a significant cause of mortality with an unfavorable continuously amplified socio-economic impact. The increased drug resistance and constant viral replication have been the trigger for important studies regarding the use of nanotechnology in antiviral therapies. Nanomaterials offer unique physico-chemical properties that have linked benefits for drug delivery as ideal tools for viral treatment. Currently, different types of nanomaterials namely nanoparticles, liposomes, nanospheres, nanogels, nanosuspensions and nanoemulsions were studied either in vitro or in vivo for drug delivery of antiviral agents with prospects to be translated in clinical practice. This review highlights the drug delivery nanosystems incorporating the major antiviral classes and their transport across specific barriers at cellular and intracellular level. Important reflections on nanomedicines currently approved or undergoing investigations for the treatment of viral infections are also discussed. Finally, the authors present an overview on the requirements for the design of antiviral nanotherapeutics.

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Drug-encapsulated carbon (DECON): A novel platform for enhanced drug delivery

Cited by 51 publications

References 47 publications

Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano) for Ocular Delivery of Cyclosporine-A

Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano) for Ocular Delivery of Cyclosporine-A

Herpes Simplex Virus: The Hostile Guest That Takes Over Your Home

Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers

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