Drug-eluting Stents: Potential Applications for Peripheral Arterial Occlusive Disease

Duda, Stephan H.; Poerner, Tudor C.; Wiesinger, Benjamin; Rundback, John H.; Tepe, Gunnar; Wiskirchen, Jakub; Haase, Karl K.

doi:10.1097/01.rvi.0000058423.01661.57

Cited by 91 publications

(76 citation statements)

References 67 publications

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“…With DESs, a need for prolonged treatment with clopidogrel is well accepted. 5,7,15 Currently, there are no data that support the influence of clopidogrel on neointimal formation and restenosis.…”

Section: Discussionmentioning

confidence: 99%

Prevention of Carotid Artery Restenosis After Sirolimus-Coated Stent Implantation in Pigs

Tepe

Muschick²,

Laule³

et al. 2006

Stroke

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Background and Purpose-To test the feasibility of self-expanding drug-coated nitinol stents for prevention of restenosis in an animal model. Stent implantation in the carotid artery (CA) has been shown to be feasible for treatment of CA stenosis. Even though the restenosis rate in CA is reported to be lower than in the coronary and peripheral arteries, problems may arise with increasing numbers of treated patients and lengthier follow-up. Methods-After predilatation with 8-mm balloons, 8 Goettinger minipigs were randomly selected to receive a sirolimus-eluting self-expanding nitinol stent (7 mm/80 mm) as well as the same stent without sirolimus/polymer coating in the right or left CA. Aspirin was given starting 3 days before the intervention and administered for an additional 4 weeks. Clopidogrel was administered for 10 days. Results-After 6 weeks, 2 subacute occlusions were observed in both groups. In the remaining vessels, the neointima was significantly reduced by sirolimus/polymer-coated stents (5.9Ϯ2.5 versus 0.7Ϯ1.0 mm 2 ). Conclusions-Sirolimus self-expanding nitinol stents may be an effective tool in reducing neointimal formation in CA.(Stroke. 2006;37:492-494.)

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Section: Discussionmentioning

confidence: 99%

Prevention of Carotid Artery Restenosis After Sirolimus-Coated Stent Implantation in Pigs

Tepe

Muschick²,

Laule³

et al. 2006

Stroke

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“…23,24 Proposed strategies to augment angioplasty technical success rates and inhibit late restenosis include cutting balloons; subintimal recanalization techniques; and bare, drug-eluting, or even magnesium alloy bioabsorbable stents. 13,[25][26][27][28] Although stenting of the tibial arteries is usually reserved as a bailout procedure and published data are limited, 11,12,28 experience with the utilization of stents in the infrapopliteal territory is being accumulated. 6,29 In our study, initial technical success was high in both arms of the study, with the exception of one MAE; there was no case of distal macroembolization, and the hospitalization period was short.…”

Section: Discussionmentioning

confidence: 99%

Sirolimus-Eluting Versus Bare Stents for Bailout After Suboptimal Infrapopliteal Angioplasty for Critical Limb Ischemia: 6-Month Angiographic Results From a Nonrandomized Prospective Single-Center Study

Siablis¹,

Kraniotis²,

Karnabatidis³

et al. 2005

Journal of Endovascular Therapy

108

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ࡗ ࡗPurpose: To report the 6-month angiographic results from a prospective single-center study investigating the efficacy and outcome of sirolimus-eluting stents used for bailout after infrapopliteal revascularization of patients with critical limb ischemia (CLI Results: Hyperlipidemia and symptomatic cardiac and carotid diseases were more pronounced in group S (pϽ0.05). Technical success was 96.6% (28/29 limbs) in group B versus 100.0% in group S (pϭ0.16). Six-month primary patency was 68.1% in group B versus 92.0% in group S (pϽ0.002). Binary in-stent and in-segment restenosis rates were 55.3% and 66.0%, respectively, in patients with bare stents versus 4.0% and 32.0%, respectively, in patients treated with the sirolimus-eluting stents (both pϽ0.001). The target lesion reintervention rate at 6 months was 17.0% in group B versus 4.0% in group S (pϭ0.02). Limb salvage was 100% in both groups. Six-month mortality and minor amputation rates were 6.9% and 17.2%, respectively, in group B versus 10.3% and 3.4%, respectively, in group S (pϭ0.32 and pϭ0.04, respectively). Conclusions: Sirolimus-eluting stents seem to restrict neointimal hyperplasia in the infrapopliteal vascular bed. J Endovasc Ther 2005;12:685-695

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“…Sirolimus-eluting stents have been used in the large majority of published studies in coronary ischemia and in peripheral artery disease. Although data in coronary ischemic disease (58) are encouraging, those in peripheral artery disease (59) are to some extent disappointing. This may raise some concern about the real effectiveness of the procedure in the stenosis of the renal graft artery.…”

Section: Treatmentmentioning

confidence: 99%

Transplant Renal Artery Stenosis

Bruno

Remuzzi

Ruggenenti

2004

Journal of the American Society of Nephrology

287

141

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Abstract. Transplant renal artery stenosis (TRAS) is a recognized, potentially curable cause of posttransplant arterial hypertension, allograft dysfunction, and graft loss. It usually occurs 3 mo to 2 yr after transplantation, but early or later presentations are not uncommon. The prevalence ranges widely from 1 to 23% in different series, reflecting the heterogeneous criteria used to establish the diagnosis, the different manner of preservation of the graft, and surgical expertise. Reported cases are progressively increasing in parallel with the use of non-invasive investigation procedures, such as Doppler ultrasonography and magnetic resonance (MR) angiography,

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Drug-eluting Stents: Potential Applications for Peripheral Arterial Occlusive Disease

Cited by 91 publications

References 67 publications

Prevention of Carotid Artery Restenosis After Sirolimus-Coated Stent Implantation in Pigs

Prevention of Carotid Artery Restenosis After Sirolimus-Coated Stent Implantation in Pigs

Sirolimus-Eluting Versus Bare Stents for Bailout After Suboptimal Infrapopliteal Angioplasty for Critical Limb Ischemia: 6-Month Angiographic Results From a Nonrandomized Prospective Single-Center Study

Transplant Renal Artery Stenosis

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