Drug Effects on Fear and Frustration: Possible Limbic Site of Action of Minor Tranquilizers

Gray, Jeffrey A.

doi:10.1007/978-1-4684-3180-3_10

Cited by 243 publications

(108 citation statements)

References 331 publications

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“…This mechanism is compatible with several previous theories that have suggested a relationship among motivation, emotion, and cognitive processes that control the basic survival systems of feeding and avoidance behavior (e.g., Buck, 1985;Gray, 1977Gray, , 1991Panksepp, 1982). Motivation, affect, and cognition are considered to be part of an integrated, adaptive, goaldirected appetitive/avoidance mechanism.…”

Section: Affective Balance and The Cognitive-emotional Forager (Cef) supporting

confidence: 90%

A neural network model of foraging decisions made under predation risk

Coleman

Brown

Levine

et al. 2005

Cognitive, Affective, & Behavioral Neuroscience

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This article develops the cognitive-emotional forager (CEF) model, a novel application of a neural network to dynamical processes in foraging behavior. The CEF is based on a neural network known as the gated dipole, introduced by Grossberg, which is capable of representing short-term affective reactions in a manner similar to Solomon and Corbit's (1974) opponent process theory. The model incorporates a trade-off between approach toward food and avoidance of predation under varying levels of motivation induced by hunger. The results of simulations in a simple patch selection paradigm, using a lifetime fitness criterion for comparison, indicate that the CEF model is capable of nearly optimal foraging and outperforms a run-of-luck rule-of-thumb model. Models such as the one presented here can illuminate the underlying cognitive and motivational components of animal decision making.

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Section: Affective Balance and The Cognitive-emotional Forager (Cef) supporting

confidence: 90%

A neural network model of foraging decisions made under predation risk

Coleman

Brown

Levine

et al. 2005

Cognitive, Affective, & Behavioral Neuroscience

View full text Add to dashboard Cite

show abstract

“…Moreover, drugs classified as anxiolytics in humans tend to reduce the behavioral effects of unexpected downward shifts of reward, such as the consummatory suppression of the postshift reinforcer and the augmented ambulatory and rearing behaviors (Gray, 1977(Gray, , 1982Mustaca, Bentosela, & Papini, 2000).…”

Section: Discussionmentioning

confidence: 99%

Anxiolytic-like effect of ejaculation upon frustration

Freidin

Kamenetzky

Mustaca

2005

Learning & Behavior

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“…Interestingly, a lack of reinforcement after a response can induce a frustration caused by the non-delivery of an expected reward ('frustrative non-reward';Dantzer, 1977;Gray, 1977). Thus, it cannot be excluded that daily exposure to DRL-72 s procedureFand its intrinsic 'frustrative nonreward' componentFcould induce a chronic state of stress accompanied by an alteration of the HPA axis function.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant-Like Effects of the Corticotropin-Releasing Factor 1 Receptor Antagonist, SSR125543, and the Vasopressin 1b Receptor Antagonist, SSR149415, in a DRL-72 s Schedule in the Rat

Louis

Cohen

Depoortère

et al. 2006

Neuropsychopharmacol

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The vasopressin 1b receptor antagonist, SSR149415, and the corticotropin-releasing factor 1 receptor antagonist, SSR125543, are orally active non-peptidic compounds with anxiolytic-and antidepressant-like activities in animal models. Presently, SSR149415 and SSR125543 were evaluated in a differential reinforcement of low-rate 72 s (DRL-72 s) schedule, a procedure known to respond differentially to antidepressants and anxiolytics. Male Wistar rats were trained to lever-press for food reinforcement, but only lever-presses occurring after a 72 s delay were reinforced; otherwise, presses were not rewarded, and the timer was reset to 0 s. The selective serotonin reuptake inhibitor, fluoxetine, and the benzodiazepine anxiolytic, diazepam, were tested in parallel. SSR149415 (10-30 mg/kg, i.p.) and SSR125543 (30 mg/kg, i.p.) increased the percentage of responses emitted in the inter-response time (IRT) bin (49-96 s), which resulted in a greater number of reinforced presses. Both compounds shifted the frequency distribution of responses toward longer IRT durations, with a preservation of the bell shape of the IRT distribution curve. Fluoxetine (10 mg/kg, i.p.) had an effect on DRL-72 s similar to that of SSR149415 and SSR125543. By contrast, diazepam increased the number of responses in IRT bin (0-12 s), and the IRT distribution curve was shifted toward shorter IRT durations and flattened. In summary, these results show that SSR149415 and SSR125543 displayed antidepressant-like activity in a DRL-72 s schedule in rat, confirming their therapeutic potential for the treatment of pathological states induced by chronic frustration such as depression.

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Drug Effects on Fear and Frustration: Possible Limbic Site of Action of Minor Tranquilizers

Cited by 243 publications

References 331 publications

A neural network model of foraging decisions made under predation risk

A neural network model of foraging decisions made under predation risk

Anxiolytic-like effect of ejaculation upon frustration

Antidepressant-Like Effects of the Corticotropin-Releasing Factor 1 Receptor Antagonist, SSR125543, and the Vasopressin 1b Receptor Antagonist, SSR149415, in a DRL-72 s Schedule in the Rat

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