Drug Effects on Agonistic Behavior

Miczek, Klaus A.; Kršiak, M

doi:10.1016/b978-0-12-004702-4.50009-6

Cited by 74 publications

(32 citation statements)

References 143 publications

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“…Overa!l, present results are generally in accord with the main body of literature on the effects of benzodiazepines on defensive behavior in animais. Thus, for several species and a variety of stimu!us contexts, these minor tranquilizers have been shown to inhibit defensive threat and attack elements at relatively low doses (Miczek and Barry 1976;Dantzer 1977;Miczek and Krsiak 1979;Rodgers and Waters 1985;Miczek 1987). Historically, however, the specificity of benzodiazepine inhibition of attack-related behaviors has been repeatedly questioned with claims and counter-claims concerning the potential contribution of a sedative component.…”

Section: Discussjo~mentioning

confidence: 96%

“…For instance, depending upon the specific control test employed, the EDso ataxia value for chlordiazepoxide has been reported to range from 9.2 to 415 mg/kg (Rodgers and Waters 1985). As such, it has been cogently argued that the only valid method for assessing the behavioral specificity of drugs is to determine their effects on a wide range of behaviors within the same test situation (Avis 1974;Krsiak 1979;Miczek and Krsiak 1979;Rodgers 1981;Rodgers and Waters 1985).…”

Section: Discussjo~mentioning

confidence: 98%

“…More detailed analyses of the "anti-aggressive" effects of benzodiazepines have revealed that defensive behavior is very much more sensitive to these drugs than is offensive behavior (for review, see Miczek and Barry 1976;Dantzer 1977;Krsiak 1979 ;Krsiak et al 1981 ;Miczek and Krsiak 1979 ;Rodgers and Waters 1985;Miczek 1987).…”

mentioning

confidence: 98%

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Attenuation of defensive threat and attack in wild rats (Rattus rattus) by benzodiazepines

Hori

Rodgers

et al. 1989

Psychopharmacology

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A battery of tests designed to elicit reactions to a variety of non-painful threat stimuli was used to study the effects of chlordiazepoxide (5-20 mg/kg), diazepam (1-5 mg/kg) and midazolam (1-10 mg/kg) on the defensive repertoire of wild Rattus rattus. The most consistent effect of benzodiazepine treatment, across compounds and tests, was a marked reduction in defensive threat and attack behaviors, with midazolam effective over a wider range of situations. In contrast, effects on freezing and flight reactions were more variable, differing substantially as a function of stimulus context. The general profile of observed changes in defense cannot be explained in terms of either non-specific behavioral suppression or a global reduction in defensiveness. Rather, our findings suggest that benzodiazepines may primarily induce a shift within the defense repertoire.

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Section: Discussjo~mentioning

confidence: 96%

Section: Discussjo~mentioning

confidence: 98%

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Attenuation of defensive threat and attack in wild rats (Rattus rattus) by benzodiazepines

Hori

Rodgers

et al. 1989

Psychopharmacology

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“…To examine aggressive behaviour, the resident intruder test was used [55,56]. In this model, the resident mice were separated from their cage mates and isolated in separate cages for 10 days prior to the experiment.…”

Section: Animals and Methodsmentioning

confidence: 99%

Increased Aggression, Improved Spatial Memory, and Reduced Anxiety-Like Behaviour in Adult Male Mice Exposed to Fluoxetine Early in Life

Kiryanova

Dyck

2014

Dev Neurosci

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Rationale: Fluoxetine (Flx; brand names Prozac, Sarafem, Rapiflux), a selective serotonin reuptake inhibitor, is prescribed for the treatment of depression in pregnant women; however, this commonly prescribed medication could affect fetal brain development as Flx crosses the placenta. The available data concerning the anatomical and behavioural consequences of perinatal exposure to Flx during early development on adult behaviour are limited and often contradictory. Objectives: To further delineate the long-term behavioural effects of altering 5-HT during development, we examined the effects of perinatal Flx exposure on the behaviour of male mice as adults. Methods: Dams were treated with approximately 25 mg/kg/day of Flx from embryonic day 15 to postnatal day 12, and the behaviour of the adult offspring was assessed. Results: We found that perinatal Flx exposure leads to increased aggression, improved spatial memory, and reduced anxiety-like behaviour. This exposure did not cause memory deficits, changes in sensory processing, or changes in gross motor function. Conclusions: Our results suggest that while perinatal exposure to Flx may have long-term effects on adult behaviour, these effects appear limited and not necessarily detrimental.

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“…Grant (112) provided an ethological description of male rat social and agonistic behavior, which includes sequence and pathway analysis, displacement and ambivalence activities, and features of sociosexual behaviors. An updated version is in Miczek and Krsiak (113). Play fighting and actual aggressive behavior are often difficult to distinguish in this species (70,114,115).…”

Section: Adult Aggressive and Sexual Patternsmentioning

confidence: 99%

Appropriate end points for the characterization of behavioral changes in developmental toxicology.

Cuomo

Salvia

Petruzzi

et al. 1996

Environ Health Perspect

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The present paper is devoted to second-and higher-tier test methods for the characterization of behavioral changes produced in rodents by exposure to noxious agents during development. The paper analyzes a series of end points that are informative about specific processes and underlying regulatory mechanisms but require greater technical sophistication and larger investments than first-tier end points. This applies to ultrasonic emissions in successive postnatal periods; to mother-pup interactions, including appropriate cross-fostering controls; to social (including sexual) interaction tests from the infantile to the young adult stage; and to a variety of conditioning and learning tests using both positive and negative reinforcement. Environ Health Perspect 104(Suppl 2): 307-315 (1996)

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Drug Effects on Agonistic Behavior

Cited by 74 publications

References 143 publications

Attenuation of defensive threat and attack in wild rats (Rattus rattus) by benzodiazepines

Attenuation of defensive threat and attack in wild rats (Rattus rattus) by benzodiazepines

Increased Aggression, Improved Spatial Memory, and Reduced Anxiety-Like Behaviour in Adult Male Mice Exposed to Fluoxetine Early in Life

Appropriate end points for the characterization of behavioral changes in developmental toxicology.

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